Androgen receptors in a Syrian hamster ductus deferens tumour cell line

James S. Norris, Jack Gorski, Peter O. Kohler

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


WE have established in culture a cloned line of hamster ductus deferens cells that contains a saturable, high affinity testosterone receptor protein. These cells exhibit an increased rate of DNA synthesis in response to testosterone and 5α-dihydrotestosterone (DHT) treatment, although they probably do not require either androgen for survival. We believe this is the first description of a cloned cell line that exhibits a growth response to a physiological dose of androgen. The mechanism of action of the steroid may be similar to that in the normal tissue of origin.

Original languageEnglish (US)
Pages (from-to)422-424
Number of pages3
Issue number5447
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Androgen receptors in a Syrian hamster ductus deferens tumour cell line'. Together they form a unique fingerprint.

Cite this