TY - JOUR
T1 - Angiomatoid melanoma
T2 - A case of metastatic melanoma mimicking a vascular malignancy
AU - Adler, Michael J.
AU - Beckstead, Jay
AU - White, Clifton R.
PY - 1997
Y1 - 1997
N2 - We present a case of melanoma metastatic to forehead skin and sacral vertebra, without known primary, which, in the cutaneous metastasis, displayed striking histologic features suggesting vascular differentiation. Histopathologic examination of the lesion revealed a large, deeply extending spindle cell malignancy with numerous, cavernous, erythrocyte-filled spaces throughout and only scant melanin pigmentation, making initial diagnosis challenging. The neoplastic cells demonstrated positive staining with antibodies to S-100 protein, HMB 45, and vimentin. We suggest the term angiomatoid melanoma for this histopathologic variant.
AB - We present a case of melanoma metastatic to forehead skin and sacral vertebra, without known primary, which, in the cutaneous metastasis, displayed striking histologic features suggesting vascular differentiation. Histopathologic examination of the lesion revealed a large, deeply extending spindle cell malignancy with numerous, cavernous, erythrocyte-filled spaces throughout and only scant melanin pigmentation, making initial diagnosis challenging. The neoplastic cells demonstrated positive staining with antibodies to S-100 protein, HMB 45, and vimentin. We suggest the term angiomatoid melanoma for this histopathologic variant.
KW - Angiomatoid metastatic melanoma
KW - Malignancy
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U2 - 10.1097/00000372-199712000-00010
DO - 10.1097/00000372-199712000-00010
M3 - Article
C2 - 9415619
AN - SCOPUS:0030827434
SN - 0193-1091
VL - 19
SP - 606
EP - 609
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 6
ER -