Antihypertensive therapy in experimental diabetes

Sharon Anderson

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Systemic hypertension is an important risk factor for the progression of diabetic glomerular disease. Recognition of this detrimental aspect has prompted intensive investigation into the mechanisms by which systemic hypertension promotes diabetic glomerulopathy, as well as into potential benefits of antihypertensive therapy. Studies in diabetic rats, both normotensive and hypertensive, have established that certain antihypertensive regimens effectively slow the development of albuminuria and glomerular sclerosis. Most consistently effective have been angiotensin-converting enzyme inhibitors, which may act to protect the kidney by several different mechanisms. Other antihypertensive regimens have been less consistent.

Original languageEnglish (US)
Pages (from-to)S86-S90
JournalJournal of the American Society of Nephrology
Issue number4 SUPPL.
StatePublished - Oct 1992


  • Albuminuria
  • Angiotensin
  • Diabetes
  • Hypertension

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Antihypertensive therapy in experimental diabetes'. Together they form a unique fingerprint.

Cite this