Apalutamide and Overall Survival in Prostate Cancer

Matthew R. Smith; Fred Saad; Simon Chowdhury; Stéphane Oudard; Boris A. Hadaschik; Julie N. Graff; David Olmos; Paul N. Mainwaring; Ji Youl Lee; Hiroji Uemura; Peter De Porre; Andressa A. Smith; Sabine D. Brookman-May; Susan Li; Ke Zhang; Brendan Rooney; Angela Lopez-Gitlitz; Eric J. Small

doi:10.1016/j.eururo.2020.08.011

Apalutamide and Overall Survival in Prostate Cancer

Matthew R. Smith, Fred Saad, Simon Chowdhury, Stéphane Oudard, Boris A. Hadaschik, Julie N. Graff, David Olmos, Paul N. Mainwaring, Ji Youl Lee, Hiroji Uemura, Peter De Porre, Andressa A. Smith, Sabine D. Brookman-May, Susan Li, Ke Zhang, Brendan Rooney, Angela Lopez-Gitlitz, Eric J. Small

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Apalutamide increased overall survival and delayed time to initiation of cytotoxic chemotherapy versus placebo in patients with nonmetastatic castration-resistant prostate cancer. Prior analyses had demonstrated clinically impactful improvement in metastasis-free survival, time to symptomatic progression, and second progression-free survival with apalutamide.

Original language	English (US)
Pages (from-to)	150-158
Number of pages	9
Journal	European Urology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/j.eururo.2020.08.011
State	Published - Jan 2021

Keywords

Apalutamide
Nonmetastatic castration-resistant prostate cancer
Overall survival
Subsequent therapy
Time to cytotoxic chemotherapy

ASJC Scopus subject areas

Urology

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10.1016/j.eururo.2020.08.011

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Smith, M. R., Saad, F., Chowdhury, S., Oudard, S., Hadaschik, B. A., Graff, J. N., Olmos, D., Mainwaring, P. N., Lee, J. Y., Uemura, H., De Porre, P., Smith, A. A., Brookman-May, S. D., Li, S., Zhang, K., Rooney, B., Lopez-Gitlitz, A., & Small, E. J. (2021). Apalutamide and Overall Survival in Prostate Cancer. European Urology, 79(1), 150-158. https://doi.org/10.1016/j.eururo.2020.08.011

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title = "Apalutamide and Overall Survival in Prostate Cancer",

abstract = "Apalutamide increased overall survival and delayed time to initiation of cytotoxic chemotherapy versus placebo in patients with nonmetastatic castration-resistant prostate cancer. Prior analyses had demonstrated clinically impactful improvement in metastasis-free survival, time to symptomatic progression, and second progression-free survival with apalutamide.",

keywords = "Apalutamide, Nonmetastatic castration-resistant prostate cancer, Overall survival, Subsequent therapy, Time to cytotoxic chemotherapy",

author = "Smith, {Matthew R.} and Fred Saad and Simon Chowdhury and St{\'e}phane Oudard and Hadaschik, {Boris A.} and Graff, {Julie N.} and David Olmos and Mainwaring, {Paul N.} and Lee, {Ji Youl} and Hiroji Uemura and {De Porre}, Peter and Smith, {Andressa A.} and Brookman-May, {Sabine D.} and Susan Li and Ke Zhang and Brendan Rooney and Angela Lopez-Gitlitz and Small, {Eric J.}",

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year = "2021",

month = jan,

doi = "10.1016/j.eururo.2020.08.011",

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AU - Smith, Matthew R.

AU - Saad, Fred

AU - Chowdhury, Simon

AU - Oudard, Stéphane

AU - Hadaschik, Boris A.

AU - Graff, Julie N.

AU - Olmos, David

AU - Mainwaring, Paul N.

AU - Lee, Ji Youl

AU - Uemura, Hiroji

AU - De Porre, Peter

AU - Smith, Andressa A.

AU - Brookman-May, Sabine D.

AU - Li, Susan

AU - Zhang, Ke

AU - Rooney, Brendan

AU - Lopez-Gitlitz, Angela

AU - Small, Eric J.

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AB - Apalutamide increased overall survival and delayed time to initiation of cytotoxic chemotherapy versus placebo in patients with nonmetastatic castration-resistant prostate cancer. Prior analyses had demonstrated clinically impactful improvement in metastasis-free survival, time to symptomatic progression, and second progression-free survival with apalutamide.

KW - Apalutamide

KW - Nonmetastatic castration-resistant prostate cancer

KW - Overall survival

KW - Subsequent therapy

KW - Time to cytotoxic chemotherapy

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JF - European Urology

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Apalutamide and Overall Survival in Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

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