Architects in neural circuit design: Glia control neuron numbers and connectivity

Megan M. Corty, Marc R. Freeman

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


Glia serve many important functions in the mature nervous system. In addition, these diverse cells have emerged as essential participants in nearly all aspects of neural development. Improved techniques to study neurons in the absence of glia, and to visualize and manipulate glia in vivo, have greatly expanded our knowledge of glial biology and neuron-glia interactions during development. Exciting studies in the last decade have begun to identify the cellular and molecular mechanisms by which glia exert control over neuronal circuit formation. Recent findings illustrate the importance of glial cells in shaping the nervous system by controlling the number and connectivity of neurons.

Original languageEnglish (US)
Pages (from-to)395-405
Number of pages11
JournalJournal of Cell Biology
Issue number3
StatePublished - Nov 11 2013
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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