Aspergillus Keratitis with Intraocular Invasion

Steven S. Searl, Ira J. Udell, Alfredo Sadun, Newton E. Hyslop, Daniel M. Albert, Kenneth R. Kenyon

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A healthy 48-year-old man developed Aspergillus keratitis following mild corneal trauma. Intensive medical therapy, initially empirical, then guided by in vitro sensitivity testing, as well as attempts at surgical excision of the infection, were ultimately nsuccessful. The poor therapeutic response may have been due to fungal penetration of the deep corneal stromal before treatment was initiated. The clinical and histologic features of A keratitis are described and related to fungal keratitis in general. The strengths and limitations of laboratory diagnostic aids are discussed. Fungal keratitis may follow a disarmingly mild early clinical course, but requires prompt, aggressive therapy if serious complications are to be avoided.

Original languageEnglish (US)
Pages (from-to)1244-1250
Number of pages7
Issue number12
StatePublished - 1981
Externally publishedYes


  • Aspergillus fumigatus
  • fungal endophthalmitis
  • fungal keratitis

ASJC Scopus subject areas

  • Ophthalmology


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