Abstract
Background:: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods:: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results:: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P =.0032). Conclusions:: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.
Original language | English (US) |
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Pages (from-to) | 2283-2286 |
Number of pages | 4 |
Journal | Movement Disorders |
Volume | 26 |
Issue number | 12 |
DOIs | |
State | Published - Oct 2011 |
Externally published | Yes |
Keywords
- Biomarker
- GATA transcription factors
- Genome-wide association study
- Parkinson's disease
- α-synuclein
ASJC Scopus subject areas
- Neurology
- Clinical Neurology