TY - JOUR
T1 - Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood
T2 - Replication across two longitudinal samples
AU - Jones, Scott A.
AU - Morales, Angelica M.
AU - Harman, Gareth
AU - Dominguez-Savage, Kalene A.
AU - Gilbert, Sydney
AU - Baker, Fiona C.
AU - de Zambotti, Massimiliano
AU - Goldston, David B.
AU - Nooner, Kate B.
AU - Clark, Duncan B.
AU - Luna, Beatriz
AU - Thompson, Wesley K.
AU - Brown, Sandra A.
AU - Tapert, Susan F.
AU - Nagel, Bonnie J.
N1 - Publisher Copyright:
© 2023
PY - 2023/10
Y1 - 2023/10
N2 - Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12–21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10–18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala and hippocampus. Significant, replicable negative associations between subcortical volume and alcohol use were found in the hippocampus in all youth, and the caudate and thalamus in female but not male youth, with significant interactions present in the caudate, thalamus and putamen. Findings suggest a structural vulnerability to alcohol use, or a predisposition to drink alcohol based on brain structure, with female youth potentially showing heightened risk, compared to male youth.
AB - Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12–21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10–18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala and hippocampus. Significant, replicable negative associations between subcortical volume and alcohol use were found in the hippocampus in all youth, and the caudate and thalamus in female but not male youth, with significant interactions present in the caudate, thalamus and putamen. Findings suggest a structural vulnerability to alcohol use, or a predisposition to drink alcohol based on brain structure, with female youth potentially showing heightened risk, compared to male youth.
KW - Adolescence
KW - Alcohol
KW - Longitudinal
KW - MRI
KW - Replication
KW - Sex differences
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U2 - 10.1016/j.dcn.2023.101294
DO - 10.1016/j.dcn.2023.101294
M3 - Article
C2 - 37683327
AN - SCOPUS:85170426482
SN - 1878-9293
VL - 63
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
M1 - 101294
ER -