TY - JOUR
T1 - Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952
AU - Vujkovic, Marijana
AU - Kershenbaum, Aaron
AU - Wray, Lisa
AU - McWilliams, Thomas
AU - Cannon, Shannon
AU - Devidas, Meenakshi
AU - Stork, Linda
AU - Aplenc, Richard
N1 - Publisher Copyright:
© 2015 .
PY - 2015/5/27
Y1 - 2015/5/27
N2 - Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2-8.6; rs2842947, OR 2.7, 95%CI 1.1-6.8; rs2842935, OR 2.5, 95%CI 1.1-5.0; rs10925235, OR 4.9, 95%CI 1.1-25.1). One variant in SLC19A1 showed a protective effect (rs4819128, OR 0.5, 95%CI 0.3-0.9). Our study provides data that relapse risk in pediatric ALL is associated with germline variations in TPMT, MTR and SLC19A1.
AB - Genetic variation in drug detoxification pathways may influence outcomes in pediatric acute lymphoblastic leukemia (ALL). We evaluated relapse risk and 24 variants in 17 genes in 714 patients in CCG-1961. Three TPMT and 1 MTR variant were associated with increased risks of relapse (rs4712327, OR 3.3, 95%CI 1.2-8.6; rs2842947, OR 2.7, 95%CI 1.1-6.8; rs2842935, OR 2.5, 95%CI 1.1-5.0; rs10925235, OR 4.9, 95%CI 1.1-25.1). One variant in SLC19A1 showed a protective effect (rs4819128, OR 0.5, 95%CI 0.3-0.9). Our study provides data that relapse risk in pediatric ALL is associated with germline variations in TPMT, MTR and SLC19A1.
KW - Acute lymphoblastic leukemia
KW - Folate pathway
KW - Relapse
KW - SNPs
UR - http://www.scopus.com/inward/record.url?scp=84938068311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938068311&partnerID=8YFLogxK
U2 - 10.1016/j.lrr.2015.05.005
DO - 10.1016/j.lrr.2015.05.005
M3 - Article
AN - SCOPUS:84938068311
SN - 2213-0489
VL - 4
SP - 47
EP - 50
JO - Leukemia Research Reports
JF - Leukemia Research Reports
IS - 2
ER -