Atopic dermatitis

Jon M. Hanifin

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


Atopic dermatitis is a chronically relapsing inflammatory skin disease with altered immune and pharmacologic responses. Elevated serum IgE probably reflects defective immune regulation. Various other cellular immune defects rise and fall with exacerbations and remissions of skin inflammation. Increased responsiveness to cholinergic and alpha adrenergic agents may relate to abnormalities of cyclic nucleotide regulation. Recent observations of abnormal cyclic adenosine monophosphate (cAMP)-phosphodiesterase activity in atopic dermatitis may provide new insights into the pathogenesis and treatment of the disease.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalJournal of the American Academy of Dermatology
Issue number1
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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