Attempted induction of chronic portal venous hypertension with polyvinyl alcohol particles in swine

Dusan Pavcnik, Richard R. Saxon, Yasushi Kubota, Hirohiko Tanihata, Barry T. Uchida, Christopher Corless, Frederick S. Keller

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


PURPOSE: Creation of presinusoidal chronic portal venous hypertension by means of repeated portal vein (PV) embolization was explored in an attempt to improve a porcine model of transjugular intrahepatic portosystemic shunt (TIPS) patency. MATERIALS AND METHODS: Six microswine underwent weekly PV embolization for 5 weeks with a total of 10.4-12.6 g of polyvinyl alcohol (PVA) particles (0.149-0.250 mm in size). Portography, liver function tests, pressure measurement in the PV and inferior vena cava (IVC) before and after PV embolization, and histopathologic evaluation of the livers were performed. RESULTS: Transhepatic portal venography performed after each embolization demonstrated diffuse PV branch occlusion in all cases. At weekly follow-up, reconstitution of flow was demonstrated in these branches; permanent occlusion of PV branches was not achieved. The mean PV pressure elevated acutely from 17.3 mm Hg ± 0.9 to 24.5 mm Hg ± 4.2 (P < .01) after each embolization. However, the pressure always returned to baseline on the follow-up studies 1 week later. Liver function tests were normal. Histopathologic evaluation of the liver showed, in multiple PV branches, central plugs of PVA with peripheral recanalization. The liver parenchyma was otherwise normal. CONCLUSION: Massive embolizations of PV with PVA at weekly intervals failed to create permanent portal hypertension or induce hepatic fibrosis.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Issue number1
StatePublished - 1997


  • Hypertension, portal
  • Liver, blood supply
  • Liver, interventional procedure
  • Portal vein, flow dynamics
  • Shunts, portosystemic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Attempted induction of chronic portal venous hypertension with polyvinyl alcohol particles in swine'. Together they form a unique fingerprint.

Cite this