Atypical central nervous system lymphoma at the cranial base: Report of four cases

Simon M. Roman-Goldstein, Anthony Jones, John B. Delashaw, Sean McMenomey, Edward A. Neuwelt

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


OBJECTIVE AND IMPORTANCE: Primary central nervous system lymphoma is a disease with increasing incidence. Atypical presentations are becoming more frequent. CLINICAL PRESENTATION: Three patients bearing cavernous sinus lesions presented initially with periorbital pain and diplopia. Tolosa-Hunt syndrome was the initial presumptive diagnosis for two patients, and meningioma was the diagnosis for the third patient. A fourth patient presented with left ear pain, and a mass in the left internal auditory canal was thought to represent an acoustic neuroma. INTERVENTION: For all four patients, an operative pathological diagnosis was obtained and was compatible with central nervous system lymphoma. All patients were treated with osmotic blood-brain barrier disruption with intra-arterial chemotherapy using a methotrexate-based regimen. CONCLUSION: All four cases included atypical presentations of lymphoma. These cases again illustrate that a correct diagnosis cannot be obtained based only on imaging and clinical findings.

Original languageEnglish (US)
Pages (from-to)613-615
Number of pages3
Issue number3
StatePublished - Sep 1998


  • CNS lymphoma
  • Extra-axial

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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