Autoinflammation and HLA-B27: Beyond Antigen Presentation

Cailin H. Sibley

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.

Original languageEnglish (US)
Pages (from-to)460-469
Number of pages10
JournalOcular Immunology and Inflammation
Issue number4
StatePublished - Jul 3 2016


  • Autoinflammation
  • HLA-B27
  • IL-1
  • innate
  • spondyloarthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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