TY - JOUR
T1 - Autopsy findings in aids patients with mycobacterium avium complex bacteremia
AU - Torriani, Francesca J.
AU - Mc Cutchan, J. Allen
AU - Bozzette, Samuel A.
AU - Grafe, Marjorie R.
AU - Havlir, Diane V.
N1 - Funding Information:
Received 24 March 1994: revised 24 June 1994. Presented in part: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, 16 October 1993 (abstract 1406). Human experimentation guidelines of the US Department of Health and Human Services were followed and this work was reviewed and approved by the Institutional Review Board (School of Medicine) of the University of California, San Diego. Financial support: California Universitywide AIDS Research Program through the California Collaborative Treatment Group (CCTG): Swiss National Foundation for AIDS Research (92-7096). Reprints or correspondence: Dr. D. Havlir, UCSD Treatment Center, 2760 Fifth Ave.. Suite 300, San Diego. CA 92103. Present affiliation: Department of Pathology, University of Texas, Medical Branch, Galveston.
PY - 1994/12
Y1 - 1994/12
N2 - To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.
AB - To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.
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U2 - 10.1093/infdis/170.6.1601
DO - 10.1093/infdis/170.6.1601
M3 - Article
C2 - 7996004
AN - SCOPUS:0028117639
SN - 0022-1899
VL - 170
SP - 1601
EP - 1605
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -