TY - JOUR
T1 - Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement
AU - Greenberg, Michael I.
AU - Hendrickson, Robert G.
PY - 2003
Y1 - 2003
N2 - Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.
AB - Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.
KW - Baclofen
KW - GABA B agonist
KW - Intrathecal baclofen
KW - Withdrawal
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U2 - 10.1081/CLT-120018277
DO - 10.1081/CLT-120018277
M3 - Article
C2 - 12645974
AN - SCOPUS:0037288057
SN - 0731-3810
VL - 41
SP - 83
EP - 85
JO - Journal of Toxicology - Clinical Toxicology
JF - Journal of Toxicology - Clinical Toxicology
IS - 1
ER -