Bacterial pili and fimbriae

Hui Wu

doi:10.1016/B978-0-12-818619-0.00139-8

Bacterial pili and fimbriae

Hui Wu

School of Dentistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter covers our current understanding of diverse pili discovered and characterized in gram-negative bacteria. We focus on three main pili, type I and P pilus, type IV pilus, and type V pilus. We compare and contrast their assembly mechanisms, discuss their biological activities and virulent potentials, outline their environmental, genetic and biochemical regulations, and highlight their potential to become novel therapeutic targets to develop precision antiinfective therapies that circumvent emerging antimicrobial resistance and fight an epidemic of antibiotic-resistant strains in postantibiotic era.

Original language	English (US)
Title of host publication	Molecular Medical Microbiology, Third Edition
Publisher	Elsevier
Pages	127-139
Number of pages	13
ISBN (Electronic)	9780128186190
DOIs	https://doi.org/10.1016/B978-0-12-818619-0.00139-8
State	Published - Jan 1 2023

Keywords

fimbriae
P pilus
Pili
type I pilus
type IV and V pilus

ASJC Scopus subject areas

General Immunology and Microbiology

Access to Document

10.1016/B978-0-12-818619-0.00139-8

Cite this

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AB - This chapter covers our current understanding of diverse pili discovered and characterized in gram-negative bacteria. We focus on three main pili, type I and P pilus, type IV pilus, and type V pilus. We compare and contrast their assembly mechanisms, discuss their biological activities and virulent potentials, outline their environmental, genetic and biochemical regulations, and highlight their potential to become novel therapeutic targets to develop precision antiinfective therapies that circumvent emerging antimicrobial resistance and fight an epidemic of antibiotic-resistant strains in postantibiotic era.

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KW - type I pilus

KW - type IV and V pilus

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BT - Molecular Medical Microbiology, Third Edition

PB - Elsevier

ER -

Bacterial pili and fimbriae

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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