@article{c8786b1425534196b87bdad525f3f42a,
title = "Balance of yin and yang: Ubiquitylation-mediated regulation of p53 and c-Myc",
abstract = "Protein ubiquitylation has been demonstrated to play a vital role not only in mediating protein turnover but also in modulating protein activity. The stability and activity of the tumor suppressor p53 and of the oncoprotein c-Myc are no exception. Both are regulated through independent ubiquitylation by several E3 ubiquitin ligases. Interestingly, p53 and c-Myc are functionally connected by some of these E3 enzymes and their regulator ARF, although these proteins play opposite roles in controlling cell growth and proliferation. The balance of this complex ubiquitylation network and its disruption during oncogenesis will be the topics of this review.",
keywords = "Oncogenesis, Ubiquitylation, Yin and yang, c-Myc, p53",
author = "Dai, {Mu Shui} and Yetao Jin and Gallegos, {Jayme R.} and Hua Lu",
note = "Funding Information: Address all correspondence to: Hua Lu, Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239. E-mail: luh@ohsu.edu 1Tremendous progress has been made in the fields of p53 and c-Myc. Unfortunately, this review could not possibly cover all the aspects and new discoveries related to this network due to the focus of this review on ubiquitylation and its limited scope. We apologize for not being able to cite all of the publications in these fields. We hope that our review could at least touch or depict one portion of the {\textquoteleft}{\textquoteleft}big elephant{\textquoteright}{\textquoteright}—the molecular mechanisms of tumorigenesis. 2This work was supported by National Institutes of Health grants (CA095441, CA93614, and CA079721) to Hua Lu. Received 1 May 2006; Revised 1 May 2006; Accepted 26 June 2006.",
year = "2006",
doi = "10.1593/neo.06334",
language = "English (US)",
volume = "8",
pages = "630--644",
journal = "Neoplasia",
issn = "1522-8002",
publisher = "Elsevier Inc.",
number = "8",
}