Beaned: Fatal forty DDI: Diltiazem, tacrolimus, CYP3A4, P-glycoprotein

Matthew Hart, Michael P. Hutchens

Research output: Chapter in Book/Report/Conference proceedingChapter


This case discusses the pharmacokinetic interaction of tacrolimus and diltiazem, including to tacrolimus toxicity. Tacrolimus is a cytochrome P450 3A4 and intestinal P-glycoprotein substrate and diltiazem is an inhibitor.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Number of pages3
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • General Medicine


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