@article{f97c3003b30f4469945d4ec8808246ad,
title = "Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies",
abstract = "Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.",
keywords = "Acoustic startle, Aggression, Alcohol, Behavior, Breeding, Cocaine, Diazepam, Embryonic stem cell lines, Genetics, Haloperidol, Inbred strains, Knockouts, Learning, Locomotion, Memory, Mouse, Nicotine, Null mutation, Open field activity, Opiates, Parental behaviors, Prepulse inhibition, Transgenic",
author = "Crawley, {Jacqueline N.} and Belknap, {John K.} and Allan Collins and Crabbe, {John C.} and Wayne Frankel and Norman Henderson and Hitzemann, {Robert J.} and Maxson, {Stephen C.} and Miner, {Lucinda L.} and Silva, {Alcino J.} and Wehner, {Jeanne M.} and Anthony Wynshaw-Boris and Richard Paylor",
note = "Funding Information: &p.2: wledgements Preparation of this paper was supported by grants to the individual authors, including USPHS AA10760, AA06243, AG13622-01, DA-00197, DA-03194, DA05228, HD33098-01A1, MH48663, and MH53668, and from the Department of Veterans Affairs, Whitehall Foundation, Beckman Foundation, Klingenstein Foundation, McKnight Foundation, Merck Foundation, Neurofibromatosis Foundation, and Neurofibromatosis Consortium. Funding Information: This publication was initiated through the Workshop on Behavioral Phenotypes of Inbred Strains of Mice, J.N.Crawley and R. Paylor, Organizers, at The Cloisters, National Institutes of Health campus in Bethesda, Md., USA, on April 24th, 1996. Support for the preparation of this manuscript was provided by the Workshop sponsors, the National Institute of Mental Health Intramural Research Program and the National Human Genome Research Institute Intramural Research Program. Co-sponsors included the National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism Program in Genetics, National Institute on Child Health and Human Development Intramural Research Program, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke Intramural Research Program, and the National Institutes of Health Office of Behavioral and Social Sciences Research. We thank Dr. David Pickar, Chief, Experimental Therapeutics Branch, National Institute of Mental Health, for his support and encouragement in the conceptual development of this manuscript.",
year = "1997",
doi = "10.1007/s002130050327",
language = "English (US)",
volume = "132",
pages = "107--124",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "2",
}