Benefits and consequences of testosterone replacement therapy: A review

A. S. Polackwich, N. N. Tadros, K. A. Ostrowski, J. C. Hedges

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Late onset hypogonadism (LOH) is an issue of increasing concern. Studies have shown the importance of testosterone in the maintenance of homeostasis, especially with respectto bone health, sexual function, diabetes, cardiovascular risk, mental health and cognition. Much of the dysfunction in hypogonadism can be reversed or improved with testosterone replacement therapy (TRT). Physicians worry about the possible consequences of TRT, especially regardingthe prostate. By reviewingthe literature, we have found there are significam benefits to TRT, and fears of adverse effects on the prostate are largely unfounded, though there is a great need for larger studies with longer periods of follow-up, especially to evaluate adverse events.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalEuropean Endocrinology
Issue number1
StatePublished - Mar 2013


  • Aging
  • Hormone replacement
  • Late onset hypogonadism (LOH)
  • Testosterone
  • Testosterone replacement

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems


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