Better adherence with once-daily antiretroviral regimens: A meta-analysis

Jean Jacques Parienti, David R. Bangsberg, Renaud Verdon, Edward M. Gardner

Research output: Contribution to journalArticlepeer-review

205 Scopus citations


Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.

Original languageEnglish (US)
Pages (from-to)484-488
Number of pages5
JournalClinical Infectious Diseases
Issue number4
StatePublished - Feb 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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