Biomimetic dentin desensitizer based on nano-structured bioactive glass

Objectives: This study evaluated the ability of a novel sol-gel bioactive glass, in conjunction with appropriate carrier vehicles, to reduce dentinal fluid flow, with an eye toward reducing dentinal hypersensitivity. Methods: Experiments were conducted to measure the reduction in tubule fluid flow after treatment of cut tooth surfaces with sol-gel bioactive glass particles in several carrier vehicles. Surfaces were also examined after exposure to brushing and acidic solutions. A non-bioactive particulate glass was compared. Results: Tubular occlusion produced by the bioactive glass was observed via SEM and a sustained reduction in hydrodynamic conductance was measured after exposure to various fluids and brushing. Conclusions: This new material may be used with the tested carriers to significantly and durably reduce tubule fluid flow, ultimately resulting in reduced dentinal hypersensitivity.