Bladder cancer: A review of diagnosis and management

Margaret C. Metts, Jobe C. Metts, Stephen J. Milito, Charles R. Thomas

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Bladder cancer is the fourth most commonly diagnosed malignancy in men and the eighth most common in women. It represents a spectrum of disease, ranging from superficial, well-differentiated disease, which does not significantly impact survival, to highly malignant tumors for which long term survival may be dismal. Transitional-cell carcinoma, which constitutes the vast majority of bladder cancers in the United States, may develop as carcinoma in situ or as invasive carcinoma. This article focuses on transitional-cell carcinoma with a review of the major aspects of the disease, including the epidemiology, diagnosis and staging, and management (including organ preservation). Therapeutic options are explored, including surgery, radiotherapy, chemotherapy, and combined modality therapy.

Original languageEnglish (US)
Pages (from-to)285-294
Number of pages10
JournalJournal of the National Medical Association
Issue number6
StatePublished - Jun 2000
Externally publishedYes


  • Bladder cancer
  • Transitional-cell carcinoma

ASJC Scopus subject areas

  • Medicine(all)


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