TY - JOUR
T1 - Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice
AU - Gremel, Christina M.
AU - Young, Emily A.
AU - Cunningham, Christopher L.
N1 - Funding Information:
This research was supported by NIH-NIAAA grants AA016041 , AA007468 , and AA007702 . Experiments within this manuscript comply with the current laws of the United States of America.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.
AB - The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.
KW - Anterior cingulate cortex
KW - Conditioned place preference
KW - Cue-induced drug seeking
KW - Ethanol
KW - Incentive motivation
KW - Opioid receptors
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U2 - 10.1016/j.bbr.2010.12.033
DO - 10.1016/j.bbr.2010.12.033
M3 - Article
C2 - 21219940
AN - SCOPUS:79952695720
SN - 0166-4328
VL - 219
SP - 358
EP - 362
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -