Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Asim Cengiz Akbulut; Ryanne A. Arisz; Constance C.F.M.J. Baaten; Gaukhar Baidildinova; Aarazo Barakzie; Rupert Bauersachs; Jur ten Berg; Wout W.A. van den Broek; H. C.de Boer; Amandine Bonifay; Vanessa Bröker; Richard J. Buka; Hugo ten Cate; Arina J.ten Cate-Hoek; S. Cointe; C. De Luca; Ilaria De Simone; Rocio Vacik Diaz; Françoise Dignat-George; Kathleen Freson; Giulia Gazzaniga; Eric C.M. van Gorp; Anxhela Habibi; Yvonne M.C. Henskens; Aaron F.J. Iding; Abdullah Khan; Gijsje H. Koenderink; Akhil Konkoth; Romaric Lacroix; Trisha Lahiri; Wilbur Lam; Rachel E. Lamerton; Roberto Lorusso; Qi Luo; Coen Maas; Owen J.T. Mccarty; Paola E.J. van der Meijden; Joost C.M. Meijers; Adarsh K. Mohapatra; Neta Nevo; Alejandro Pallares Robles; Philippe Poncelet; Christoph Reinhardt; Wolfram Ruf; Ronald Saraswat; Claudia Schönichen; Roger Schutgens; Paolo Simioni; Stefano Spada; Henri M.H. Spronk; Karlygash Tazhibayeva; Jecko Thachil; L. Vallier; Alicia Veninga; Peter Verhamme; Chantal Visser; Steve P. Watson; Philip Wenzel; Ruth A.L. Willems; Anne Willers; Pengyu Zhang; Konstantinos Zifkos; Anton Jan van Zonneveld

doi:10.1055/a-2052-9175

Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Asim Cengiz Akbulut, Ryanne A. Arisz, Constance C.F.M.J. Baaten, Gaukhar Baidildinova, Aarazo Barakzie, Rupert Bauersachs, Jur ten Berg, Wout W.A. van den Broek, H. C.de Boer, Amandine Bonifay, Vanessa Bröker, Richard J. Buka, Hugo ten Cate, Arina J.ten Cate-Hoek, S. Cointe, C. De Luca, Ilaria De Simone, Rocio Vacik Diaz, Françoise Dignat-George, Kathleen FresonGiulia Gazzaniga, Eric C.M. van Gorp, Anxhela Habibi, Yvonne M.C. Henskens, Aaron F.J. Iding, Abdullah Khan, Gijsje H. Koenderink, Akhil Konkoth, Romaric Lacroix, Trisha Lahiri, Wilbur Lam, Rachel E. Lamerton, Roberto Lorusso, Qi Luo, Coen Maas, Owen J.T. Mccarty, Paola E.J. van der Meijden, Joost C.M. Meijers, Adarsh K. Mohapatra, Neta Nevo, Alejandro Pallares Robles, Philippe Poncelet, Christoph Reinhardt, Wolfram Ruf, Ronald Saraswat, Claudia Schönichen, Roger Schutgens, Paolo Simioni, Stefano Spada, Henri M.H. Spronk, Karlygash Tazhibayeva, Jecko Thachil, L. Vallier, Alicia Veninga, Peter Verhamme, Chantal Visser, Steve P. Watson, Philip Wenzel, Ruth A.L. Willems, Anne Willers, Pengyu Zhang, Konstantinos Zifkos, Anton Jan van Zonneveld

Research output: Contribution to journal › Article › peer-review

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Abstract

The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.

Original language	English (US)
Journal	Thrombosis and Haemostasis
DOIs	https://doi.org/10.1055/a-2052-9175
State	Accepted/In press - 2022

ASJC Scopus subject areas

Hematology

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Akbulut, A. C., Arisz, R. A., Baaten, C. C. F. M. J., Baidildinova, G., Barakzie, A., Bauersachs, R., Berg, J. T., van den Broek, W. W. A., Boer, H. C. D., Bonifay, A., Bröker, V., Buka, R. J., Cate, H. T., Cate-Hoek, A. J. T., Cointe, S., Luca, C. D., Simone, I. D., Diaz, R. V., Dignat-George, F., ... Zonneveld, A. J. V. (Accepted/In press). Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis. https://doi.org/10.1055/a-2052-9175

Akbulut, AC, Arisz, RA, Baaten, CCFMJ, Baidildinova, G, Barakzie, A, Bauersachs, R, Berg, JT, van den Broek, WWA, Boer, HCD, Bonifay, A, Bröker, V, Buka, RJ, Cate, HT, Cate-Hoek, AJT, Cointe, S, Luca, CD, Simone, ID, Diaz, RV, Dignat-George, F, Freson, K, Gazzaniga, G, van Gorp, ECM, Habibi, A, Henskens, YMC, Iding, AFJ, Khan, A, Koenderink, GH, Konkoth, A, Lacroix, R, Lahiri, T, Lam, W, Lamerton, RE, Lorusso, R, Luo, Q, Maas, C, Mccarty, OJT, van der Meijden, PEJ, Meijers, JCM, Mohapatra, AK, Nevo, N, Robles, AP, Poncelet, P, Reinhardt, C, Ruf, W, Saraswat, R, Schönichen, C, Schutgens, R, Simioni, P, Spada, S, Spronk, HMH, Tazhibayeva, K, Thachil, J, Vallier, L, Veninga, A, Verhamme, P, Visser, C, Watson, SP, Wenzel, P, Willems, RAL, Willers, A, Zhang, P, Zifkos, K & Zonneveld, AJV 2022, 'Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis', Thrombosis and Haemostasis. https://doi.org/10.1055/a-2052-9175

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title = "Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis",

abstract = "The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.",

author = "Akbulut, {Asim Cengiz} and Arisz, {Ryanne A.} and Baaten, {Constance C.F.M.J.} and Gaukhar Baidildinova and Aarazo Barakzie and Rupert Bauersachs and Berg, {Jur ten} and {van den Broek}, {Wout W.A.} and Boer, {H. C.de} and Amandine Bonifay and Vanessa Br{\"o}ker and Buka, {Richard J.} and Cate, {Hugo ten} and Cate-Hoek, {Arina J.ten} and S. Cointe and Luca, {C. De} and Simone, {Ilaria De} and Diaz, {Rocio Vacik} and Fran{\c c}oise Dignat-George and Kathleen Freson and Giulia Gazzaniga and {van Gorp}, {Eric C.M.} and Anxhela Habibi and Henskens, {Yvonne M.C.} and Iding, {Aaron F.J.} and Abdullah Khan and Koenderink, {Gijsje H.} and Akhil Konkoth and Romaric Lacroix and Trisha Lahiri and Wilbur Lam and Lamerton, {Rachel E.} and Roberto Lorusso and Qi Luo and Coen Maas and Mccarty, {Owen J.T.} and {van der Meijden}, {Paola E.J.} and Meijers, {Joost C.M.} and Mohapatra, {Adarsh K.} and Neta Nevo and Robles, {Alejandro Pallares} and Philippe Poncelet and Christoph Reinhardt and Wolfram Ruf and Ronald Saraswat and Claudia Sch{\"o}nichen and Roger Schutgens and Paolo Simioni and Stefano Spada and Spronk, {Henri M.H.} and Karlygash Tazhibayeva and Jecko Thachil and L. Vallier and Alicia Veninga and Peter Verhamme and Chantal Visser and Watson, {Steve P.} and Philip Wenzel and Willems, {Ruth A.L.} and Anne Willers and Pengyu Zhang and Konstantinos Zifkos and Zonneveld, {Anton Jan van}",

year = "2022",

doi = "10.1055/a-2052-9175",

language = "English (US)",

journal = "Thrombosis and Haemostasis",

issn = "0340-6245",

publisher = "Schattauer GmbH",

}

TY - JOUR

T1 - Blood coagulation and beyond

T2 - Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

AU - Akbulut, Asim Cengiz

AU - Arisz, Ryanne A.

AU - Baaten, Constance C.F.M.J.

AU - Baidildinova, Gaukhar

AU - Barakzie, Aarazo

AU - Bauersachs, Rupert

AU - Berg, Jur ten

AU - van den Broek, Wout W.A.

AU - Boer, H. C.de

AU - Bonifay, Amandine

AU - Bröker, Vanessa

AU - Buka, Richard J.

AU - Cate, Hugo ten

AU - Cate-Hoek, Arina J.ten

AU - Cointe, S.

AU - Luca, C. De

AU - Simone, Ilaria De

AU - Diaz, Rocio Vacik

AU - Dignat-George, Françoise

AU - Freson, Kathleen

AU - Gazzaniga, Giulia

AU - van Gorp, Eric C.M.

AU - Habibi, Anxhela

AU - Henskens, Yvonne M.C.

AU - Iding, Aaron F.J.

AU - Khan, Abdullah

AU - Koenderink, Gijsje H.

AU - Konkoth, Akhil

AU - Lacroix, Romaric

AU - Lahiri, Trisha

AU - Lam, Wilbur

AU - Lamerton, Rachel E.

AU - Lorusso, Roberto

AU - Luo, Qi

AU - Maas, Coen

AU - Mccarty, Owen J.T.

AU - van der Meijden, Paola E.J.

AU - Meijers, Joost C.M.

AU - Mohapatra, Adarsh K.

AU - Nevo, Neta

AU - Robles, Alejandro Pallares

AU - Poncelet, Philippe

AU - Reinhardt, Christoph

AU - Ruf, Wolfram

AU - Saraswat, Ronald

AU - Schönichen, Claudia

AU - Schutgens, Roger

AU - Simioni, Paolo

AU - Spada, Stefano

AU - Spronk, Henri M.H.

AU - Tazhibayeva, Karlygash

AU - Thachil, Jecko

AU - Vallier, L.

AU - Veninga, Alicia

AU - Verhamme, Peter

AU - Visser, Chantal

AU - Watson, Steve P.

AU - Wenzel, Philip

AU - Willems, Ruth A.L.

AU - Willers, Anne

AU - Zhang, Pengyu

AU - Zifkos, Konstantinos

AU - Zonneveld, Anton Jan van

PY - 2022

Y1 - 2022

N2 - The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.

AB - The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.

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DO - 10.1055/a-2052-9175

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JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

ER -

Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

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