TY - JOUR
T1 - Blood pressure and mesenteric resistance arterial function after spaceflight
AU - Hatton, Daniel C.
AU - Yue, Qi
AU - Chapman, Justin
AU - Xue, Hong
AU - Dierickx, Jacqueline
AU - Roullet, Chantal
AU - Coste, Sarah
AU - Roullet, Jean Baptiste
AU - McCarron, David A.
PY - 2002
Y1 - 2002
N2 - Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.
AB - Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.
KW - Microgravity
KW - Spontaneously hypertensive rats
KW - Vascular contraction
KW - Vascular relaxation
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U2 - 10.1152/jappl.2002.92.1.13
DO - 10.1152/jappl.2002.92.1.13
M3 - Article
C2 - 11744637
AN - SCOPUS:0036095460
SN - 8750-7587
VL - 92
SP - 13
EP - 17
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 1
ER -