TY - JOUR
T1 - Brain volumetrics across the lifespan of the rhesus macaque
AU - Dash, Steven
AU - Park, Byung
AU - Kroenke, Christopher D.
AU - Rooney, William D.
AU - Urbanski, Henryk F.
AU - Kohama, Steven G.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/6
Y1 - 2023/6
N2 - The rhesus macaque is a long-lived nonhuman primate (NHP) with a brain structure similar to humans, which may represent a valuable translational animal model in which to study human brain aging. Previous magnetic resonance imaging (MRI) studies of age in rhesus macaque brains have been prone to low statistical power, unbalanced sex ratio and lack of a complete age range. To overcome these problems, the current study surveyed structural T1-weighted magnetic resonance imaging scans of 66 animals, 34 females (aged 6-31 years) and 32 males (aged 5-27 years). Differences observed in older animals, included enlargement of the lateral ventricles and a smaller volume in the frontal cortex, caudate, putamen, hypothalamus, and thalamus. Unexpected, greater volume, were measured in older animals in the hippocampus, amygdala, and globus pallidus. There were also numerous differences between males and females with respect to age in both white and gray matter regions. As an apparent model of normative human aging, the macaque is ideal for studying induction and mitigation of neurodegenerative disease.
AB - The rhesus macaque is a long-lived nonhuman primate (NHP) with a brain structure similar to humans, which may represent a valuable translational animal model in which to study human brain aging. Previous magnetic resonance imaging (MRI) studies of age in rhesus macaque brains have been prone to low statistical power, unbalanced sex ratio and lack of a complete age range. To overcome these problems, the current study surveyed structural T1-weighted magnetic resonance imaging scans of 66 animals, 34 females (aged 6-31 years) and 32 males (aged 5-27 years). Differences observed in older animals, included enlargement of the lateral ventricles and a smaller volume in the frontal cortex, caudate, putamen, hypothalamus, and thalamus. Unexpected, greater volume, were measured in older animals in the hippocampus, amygdala, and globus pallidus. There were also numerous differences between males and females with respect to age in both white and gray matter regions. As an apparent model of normative human aging, the macaque is ideal for studying induction and mitigation of neurodegenerative disease.
KW - Aging
KW - Frontal Cortex
KW - Magnetic Resonance Imaging
KW - Rhesus Macaque
UR - http://www.scopus.com/inward/record.url?scp=85150388171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85150388171&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2023.02.002
DO - 10.1016/j.neurobiolaging.2023.02.002
M3 - Article
C2 - 36917864
AN - SCOPUS:85150388171
SN - 0197-4580
VL - 126
SP - 34
EP - 43
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -