TY - JOUR
T1 - Breast-feeding Success Among Infants With Phenylketonuria
AU - Banta-Wright, Sandra A.
AU - Shelton, Kathleen C.
AU - Lowe, Nancy D.
AU - Knafl, Kathleen A.
AU - Houck, Gail M.
N1 - Funding Information:
S.A.B.W. was supported by March of Dimes National Graduate Nurse Scholarship Award, ARC of Washington State Graduate Education Award , T-73 MC00034 : Training Grant from the Maternal–Child Health Bureau for Leadership Education in Neurodevelopmental and Related Disabilities program, and F-31 : Ruth L Kirschstein National Research Service Award (Mothers' Experience of Breastfeeding Infants with PKU; 5F31NR010963 ).
PY - 2012/8
Y1 - 2012/8
N2 - Breast milk is the nutrition of choice for human infants (American Academy of Pediatrics, 2005; American Association of Family Physicians, 2008; Association of Women's Health Obstetric and Neonatal Nurses, 2005; Canadian Paediatric Society, 2005; U.S. Preventive Services Task Force, 2008; World Health Organization, 2009). In comparison to standard commercial formula, human breast milk has a lower concentration of protein and a lower content of the amino acid phenylalanine (Phe). For infants with phenylketonuria (PKU), these attributes of human breast milk make it ideal as a base source of nutrition. The purpose of this study was to compare the incidence and duration of breast-feeding and corresponding Phe levels of breast-fed and formula-fed infants with PKU in the caseload of a pediatric metabolic clinic at an urban tertiary-care medical center. Charts were reviewed for infants diagnosed with PKU beginning with 2005 and ending with 1980, the year no further breast-feeding cases were identified in the PKU population. During the first year of life, most of the infants, whether breast-fed or formula-fed, had similar mean Phe levels. However, the frequency distributions revealed that more breast-fed infants with PKU had Phe levels within the normal range (120-360 μmol/L) and were less likely to have low Phe levels (<120 μmol/L) than formula-fed infants with PKU. Further research is needed to understand how mothers manage breast-feeding in the context of PKU.
AB - Breast milk is the nutrition of choice for human infants (American Academy of Pediatrics, 2005; American Association of Family Physicians, 2008; Association of Women's Health Obstetric and Neonatal Nurses, 2005; Canadian Paediatric Society, 2005; U.S. Preventive Services Task Force, 2008; World Health Organization, 2009). In comparison to standard commercial formula, human breast milk has a lower concentration of protein and a lower content of the amino acid phenylalanine (Phe). For infants with phenylketonuria (PKU), these attributes of human breast milk make it ideal as a base source of nutrition. The purpose of this study was to compare the incidence and duration of breast-feeding and corresponding Phe levels of breast-fed and formula-fed infants with PKU in the caseload of a pediatric metabolic clinic at an urban tertiary-care medical center. Charts were reviewed for infants diagnosed with PKU beginning with 2005 and ending with 1980, the year no further breast-feeding cases were identified in the PKU population. During the first year of life, most of the infants, whether breast-fed or formula-fed, had similar mean Phe levels. However, the frequency distributions revealed that more breast-fed infants with PKU had Phe levels within the normal range (120-360 μmol/L) and were less likely to have low Phe levels (<120 μmol/L) than formula-fed infants with PKU. Further research is needed to understand how mothers manage breast-feeding in the context of PKU.
KW - Breastfeeding
KW - Diet therapy
KW - Infant-Newborn
KW - Phenylalanine
KW - Phenylketonuria
UR - http://www.scopus.com/inward/record.url?scp=84862515125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862515125&partnerID=8YFLogxK
U2 - 10.1016/j.pedn.2011.03.015
DO - 10.1016/j.pedn.2011.03.015
M3 - Article
C2 - 22703678
AN - SCOPUS:84862515125
SN - 0882-5963
VL - 27
SP - 319
EP - 327
JO - Journal of pediatric nursing
JF - Journal of pediatric nursing
IS - 4
ER -