TY - JOUR
T1 - Broadening the growth hormone insensitivity syndrome
AU - Rosenfeld, Ron G.
PY - 1995/10/26
Y1 - 1995/10/26
N2 - The development of recombinant-DNA–derived human growth hormone (GH) has made it much easier to treat patients with GH deficiency.1 Unfortunately, establishing a firm diagnosis of this deficiency is frequently difficult, even if detailed records of growth are available and many biochemical tests are performed.2 Although the difficulties can be attributed at least in part to the pulsatile secretion of GH and the vagaries of GH assays, they also reflect the complex relation between GH and the insulin-like growth factor (IGF) axis. To be biologically active, GH must bind to a transmembrane receptor, the receptor must form a dimer, and an.
AB - The development of recombinant-DNA–derived human growth hormone (GH) has made it much easier to treat patients with GH deficiency.1 Unfortunately, establishing a firm diagnosis of this deficiency is frequently difficult, even if detailed records of growth are available and many biochemical tests are performed.2 Although the difficulties can be attributed at least in part to the pulsatile secretion of GH and the vagaries of GH assays, they also reflect the complex relation between GH and the insulin-like growth factor (IGF) axis. To be biologically active, GH must bind to a transmembrane receptor, the receptor must form a dimer, and an.
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U2 - 10.1056/NEJM199510263331709
DO - 10.1056/NEJM199510263331709
M3 - Editorial
C2 - 7565954
AN - SCOPUS:0028842556
SN - 0028-4793
VL - 333
SP - 1145
EP - 1146
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -