Burden of Illness in Painful Diabetic Peripheral Neuropathy: The Patients' Perspectives

Mugdha Gore, Nancy A. Brandenburg, Deborah L. Hoffman, Kei Sing Tai, Brett Stacey

Research output: Contribution to journalArticlepeer-review

179 Scopus citations


Our goal was to assess the patient-level burden among subjects with painful diabetic peripheral neuropathy (DPN). Community-based physicians recruited patients with painful DPN (N = 255) between April and October 2003. Patients completed a survey on pain experience (Brief Pain Inventory-DPN [BPI-DPN]), health status (EuroQoL [EQ-5D]), healthcare utilization (consults, prescription [Rx], and over-the-counter [OTC] medications), and work productivity/functioning. Patients were 61 ± 12.8 years old and had diabetes for 12 ± 10.3 years and painful DPN for 6.4 ± 6.4 years; 25.5 and 62.7% had other neuropathic and musculoskeletal pain conditions. Average and worst pain scores (BPI-DPN, 0-10 scales) were 5.0 ± 2.5 and 5.6 ± 2.8. The mean EQ-5D utility was .5 ± .3 (range = -.594-1). A majority (87.4%) took pain medications (Rx/OTC) in the preceding week: an average of 3.8 ± 3.9 Rx and 2.1 ± 1.3 OTC medications. Nearly half (46.7%) received NSAIDs. Other frequently reported medications were short/long-acting opioids (43.1%), anticonvulsants (27.1%), selective serotonin reuptake inhibitors/selective norepinephrine reuptake inhibitors (18%), and tricyclic antidepressants (11.4%). During the preceding 3 months, 59.6% had ≥2 health professional consults; 59% reported decreased home productivity; 85.5% reported activity limitations; and 64.4% of patients who worked (N = 73) reported missing work/decreased work productivity due to painful DPN. Our results underscore a substantial patient-level burden among subjects with painful DPN. Perspective: Information on the patient-level burden among painful DPN sufferers in the U.S. was previously lacking. Our results suggest that this burden is significant, evidenced by moderate-to-high pain levels, polypharmacy, health resource use, and work/activity limitations. Results also suggest suboptimal pain management and low levels of satisfaction with treatments.

Original languageEnglish (US)
Pages (from-to)892-900
Number of pages9
JournalJournal of Pain
Issue number12
StatePublished - Dec 2006
Externally publishedYes


  • Painful diabetic peripheral neuropathy
  • burden of illness
  • economic burden
  • health surveys
  • human burden
  • pain experience

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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