Calcium/calmodulin-dependent protein kinase II: role in learning and memory

Thomas R. Soderling

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Numerous studies over the past decade have established a role(s) for protein phosphorylation in modulation of synaptic efficiency. This article reviews this data and focuses on putative functions of Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) which is highly concentrated at these synapses which utilize glutamate as the neurotransmitter. Evidence is presented that CaM-kinase II can phosphorylate these glutamate receptor/ion channels and enhance the ion current flowing through them. This may contribute to mechanisms of synaptic plasticity that are important in cellular paradigms of learning and memory such as long-term potentiation in the hippocampus.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalMolecular and Cellular Biochemistry
Volume127-128
Issue number1
DOIs
StatePublished - Nov 1993
Externally publishedYes

Keywords

  • learning and memory
  • protein phosphorylation
  • synaptic plasticity

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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