Cancer cachexia: involvement of an expanding macroenvironment

Benjamin R. Pryce; David J. Wang; Teresa A. Zimmers; Michael C. Ostrowski; Denis C. Guttridge

doi:10.1016/j.ccell.2023.02.007

Cancer cachexia: involvement of an expanding macroenvironment

Benjamin R. Pryce, David J. Wang, Teresa A. Zimmers, Michael C. Ostrowski, Denis C. Guttridge

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose, but recent findings reveal an expanding tumor macroenvironment involving organ crosstalks that underlie the cachectic state.

Original language	English (US)
Pages (from-to)	581-584
Number of pages	4
Journal	Cancer Cell
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2023.02.007
State	Published - Mar 13 2023
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2023.02.007

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title = "Cancer cachexia: involvement of an expanding macroenvironment",

abstract = "Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose, but recent findings reveal an expanding tumor macroenvironment involving organ crosstalks that underlie the cachectic state.",

author = "Pryce, {Benjamin R.} and Wang, {David J.} and Zimmers, {Teresa A.} and Ostrowski, {Michael C.} and Guttridge, {Denis C.}",

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doi = "10.1016/j.ccell.2023.02.007",

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T2 - involvement of an expanding macroenvironment

AU - Pryce, Benjamin R.

AU - Wang, David J.

AU - Zimmers, Teresa A.

AU - Ostrowski, Michael C.

AU - Guttridge, Denis C.

PY - 2023/3/13

Y1 - 2023/3/13

N2 - Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose, but recent findings reveal an expanding tumor macroenvironment involving organ crosstalks that underlie the cachectic state.

AB - Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose, but recent findings reveal an expanding tumor macroenvironment involving organ crosstalks that underlie the cachectic state.

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DO - 10.1016/j.ccell.2023.02.007

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JO - Cancer Cell

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Cancer cachexia: involvement of an expanding macroenvironment

Abstract

ASJC Scopus subject areas

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