Canine distemper virus: the early blood-brain barrier lesion

M. K. Axthelm, S. Krakowka

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Experimental infection of gnotobiotic Beagle dogs with neurovirulent R252 canine distemper virus (CDV) resulted in hematogenous dissemination of virus to the central nervous system (CNS). Viral antigen was first detected within CNS capillary and venular endothelia and/or perivascular astrocytic foot processes and pericytes. The number of primary infection sites was evenly distributed throughout the neuraxis. Leukocytic infiltrations followed CNS endothelial cell infection by 1-2 days and were composed of both viral antigen-positive and-negative cells. These results indicate that CDV infection of the CNS is initiated by the interaction of circulating infectious virus with endothelial cells.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalActa Neuropathologica
Issue number1
StatePublished - Jan 1987


  • Canine distemper virus
  • Endothelium
  • Morbillivirus
  • Morbillivirus pathogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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