Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism

Pei Chun Chen; Erik M. Olson; Qing Zhou; Yelena Kryukova; Heidi M. Sampson; David Y. Thomas; Show Ling Shyng

doi:10.1074/jbc.M113.470948

Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism

Pei Chun Chen, Erik M. Olson, Qing Zhou, Yelena Kryukova, Heidi M. Sampson, David Y. Thomas, Show Ling Shyng

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background: Defective folding and trafficking of β-cell ATP-sensitive potassium (K_ATP) channels causes congenital hyperinsulinism. Results: Carbamazepine improves the processing and surface expression of trafficking-impaired K_ATP channels harboring a subset of sulfonylurea receptor 1 mutations. Conclusion: Carbamazepine is a novel corrector of KATP channels. Significance: Carbamazepine may be used to treat congenital hyperinsulinism caused by defective K_ATPchannel trafficking.

Original language	English (US)
Pages (from-to)	20942-20954
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M113.470948
State	Published - Jul 19 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.470948

Cite this

@article{602dff9325984c6ca65468531dc10b78,

title = "Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism",

abstract = "Background: Defective folding and trafficking of β-cell ATP-sensitive potassium (KATP) channels causes congenital hyperinsulinism. Results: Carbamazepine improves the processing and surface expression of trafficking-impaired KATP channels harboring a subset of sulfonylurea receptor 1 mutations. Conclusion: Carbamazepine is a novel corrector of KATP channels. Significance: Carbamazepine may be used to treat congenital hyperinsulinism caused by defective KATPchannel trafficking.",

author = "Chen, {Pei Chun} and Olson, {Erik M.} and Qing Zhou and Yelena Kryukova and Sampson, {Heidi M.} and Thomas, {David Y.} and Shyng, {Show Ling}",

year = "2013",

month = jul,

day = "19",

doi = "10.1074/jbc.M113.470948",

language = "English (US)",

volume = "288",

pages = "20942--20954",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "29",

}

TY - JOUR

T1 - Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism

AU - Chen, Pei Chun

AU - Olson, Erik M.

AU - Zhou, Qing

AU - Kryukova, Yelena

AU - Sampson, Heidi M.

AU - Thomas, David Y.

AU - Shyng, Show Ling

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: Defective folding and trafficking of β-cell ATP-sensitive potassium (KATP) channels causes congenital hyperinsulinism. Results: Carbamazepine improves the processing and surface expression of trafficking-impaired KATP channels harboring a subset of sulfonylurea receptor 1 mutations. Conclusion: Carbamazepine is a novel corrector of KATP channels. Significance: Carbamazepine may be used to treat congenital hyperinsulinism caused by defective KATPchannel trafficking.

AB - Background: Defective folding and trafficking of β-cell ATP-sensitive potassium (KATP) channels causes congenital hyperinsulinism. Results: Carbamazepine improves the processing and surface expression of trafficking-impaired KATP channels harboring a subset of sulfonylurea receptor 1 mutations. Conclusion: Carbamazepine is a novel corrector of KATP channels. Significance: Carbamazepine may be used to treat congenital hyperinsulinism caused by defective KATPchannel trafficking.

UR - http://www.scopus.com/inward/record.url?scp=84880532649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880532649&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.470948

DO - 10.1074/jbc.M113.470948

M3 - Article

C2 - 23744072

AN - SCOPUS:84880532649

SN - 0021-9258

VL - 288

SP - 20942

EP - 20954

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 29

ER -

Carbamazepine as a novel small molecule corrector of trafficking-impaired atp-sensitive potassium channels identified in congenital hyperinsulinism

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this