@article{81ee4c22063f4cd0b53c987cccdb53c3,
title = "Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO",
abstract = "Prior work has examined associations between cardiometabolic pregnancy complications and autism spectrum disorder (ASD) but not how these complications may relate to social communication traits more broadly. We addressed this question within the Environmental Inf luences on Child Health Outcomes program, with 6,778 participants from 40 cohorts conducted from 1998–2021 with information on ASD-related traits via the Social Responsiveness Scale. Four metabolic pregnancy complications were examined individually, and combined, in association with Social Responsiveness Scale scores, using crude and adjusted linear regression as well as quantile regression analyses. We also examined associations stratified by ASD diagnosis, and potential mediation by preterm birth and low birth weight, and modification by child sex and enriched risk of ASD. Increases in ASD-related traits were associated with obesity (β = 4.64, 95% confidence interval: 3.27, 6.01) and gestational diabetes (β = 5.21, 95% confidence interval: 2.41, 8.02), specifically, but not with hypertension or preeclampsia. Results among children without ASD were similar to main analyses, but weaker among ASD cases. There was not strong evidence for mediation or modification. Results suggest that common cardiometabolic pregnancy complications may inf luence child ASD-related traits, not only above a diagnostic threshold relevant to ASD but also across the population.",
keywords = "Social Responsiveness Scale, autism, cardiometabolic complications, obesity, pregnancy complications",
author = "{behalf of program collaborators for Environmental Influences on Child Health Outcomes} and Kristen Lyall and Xuejuan Ning and Aschner, {Judy L.} and Avalos, {Lyndsay A.} and Bennett, {Deborah H.} and Bilder, {Deborah A.} and Bush, {Nicole R.} and Carroll, {Kecia N.} and Chu, {Su H.} and Croen, {Lisa A.} and Dana Dabelea and Daniels, {Julie L.} and Christiane Duarte and Elliott, {Amy J.} and Fallin, {M. Daniele} and Assiamira Ferrara and Irva Hertz-Picciotto and Hipwell, {Alison E.} and Jensen, {Elizabeth T.} and Johnson, {Susan L.} and Joseph, {Robert M.} and Margaret Karagas and Kelly, {Rachel S.} and Lester, {Barry M.} and Amy Margolis and McEvoy, {Cindy T.} and Daniel Messinger and Neiderhiser, {Jenae M.} and O{\textquoteright}Connor, {Thomas G.} and Emily Oken and Sheela Sathyanarayana and Schmidt, {Rebecca J.} and Sheinkopf, {Stephen J.} and Talge, {Nicole M.} and Turi, {Kedir N.} and Wright, {Rosalind J.} and Qi Zhao and Craig Newschaffer and Volk, {Heather E.} and Christine Ladd-Acosta",
note = "Funding Information: This work was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health (award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), UH3OD023320 (J.L.A.), UH3OD023248 (D.D.), UH3OD023313 (Deoni), UH3OD023328 (C.D.), UH3OD023318 (Dunlop), UH3OD023279 (A.J.E.), UH3OD023289 (A.F., L.A.C.), UH3OD023282 (Gern), UH3OD023365 (I.H.P.), UH3OD023244 (A.E.H.), UH3OD023268 (Litonjua), UH3OD023347 (B.M.L.), UH3OD023389 (Leve), UH3OD023288 (C.T.M.), UH3OD023389 (J.M.N.), UH3OD023342 (C.N.), UH3OD023275 (M.K.), UH3OD023271 (Karr), U01HL091528 and UH3OD023349 (T.G.O.), UH3OD023286 (E.O.), UH3OD023348 (O{\textquoteright}Shea), UH3OD023285 (Paneth), UH3OD023272 (Schantz, Woodruff) UH3OD023337 (R.J.W.)). Data used for these analyses may be available through approval from individual study investigators and the Environmental Influences on Child Health Outcomes (ECHO) program. Publisher Copyright: {\textcopyright} The Author(s) 2022.",
year = "2022",
month = aug,
day = "1",
doi = "10.1093/aje/kwac061",
language = "English (US)",
volume = "191",
pages = "1407--1419",
journal = "American journal of epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "8",
}