Cardiovascular applications of therapeutic ultrasound

Babak Nazer, Edward P. Gerstenfeld, Akiko Hata, Lawrence A. Crum, Thomas J. Matula

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US's thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalJournal of Interventional Cardiac Electrophysiology
Issue number3
StatePublished - Apr 2014
Externally publishedYes


  • Ablation
  • Angiogenesis
  • Atrial fibrillation
  • Ultrasound

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Cardiovascular applications of therapeutic ultrasound'. Together they form a unique fingerprint.

Cite this