TY - JOUR
T1 - Cataracts associated with allopurinol therapy
AU - Fraunfelder, Frederick T.
AU - Hanna, Calvin
AU - Dreis, Michael W.
AU - Cosgrove, Kingsley W.
N1 - Funding Information:
The National Registry of Drug-Induced Ocular Side Effects has had a number of reports of cataracts in patients taking the Accepted for publication May 27, 1982. From the Department of Ophthalmology and the National Registry of Drug-Induced Ocular Side Ef- fects, Oregon Health Sciences University, Portland, Oregon (Dr. Fraunfelder), the Departments of Phar- macology (Dr. Hanna) and Ophthalmology (Dr. Cos- grove), University of Arkansas for Medical Sciences, Little Rock, Arkansas; and the Division of Drug that could not be reproduced in an ani-Experience,FederalFoodandDrugAdministration, mal, but allopurinol-induced cataracts Rockville, Maryland (Mr. Dreis). This study was have not been confirmed in animals. 1,2 supported in part by Contract No. 223-79-3003 from the Federal Food and Drug Administration and by However, because Lerman, Megaw, and Research to Prevent Blindness, Inc. Cardner" have now found evidence, via Reprint requests to F. T. Fraunfelder, M.D., phosphorescence emission peaks, that alDepartment of Ophthalmology, Oregon Health Sci- ences University, 3181 S.W. Sam Jackson Park Rd., lopurinol is probably present in human Portland, OR97201. cataracts and in animal and eye bank AMERICAN JOURNAL OF OPHTHALMOLOGY 94:137-140, 1982 most commonly prescribed antihyperuricemic agent, allopurinol. Although a number of clinicians have suspected a cause-and-effect relationship between this drug and lens changes, the Registry has been reluctant to publish these data since the cataracts may well be coincidence or an unrecognized result of hy- peruricemia, To date, no drug-induced human lens change has been reported
PY - 1982/8
Y1 - 1982/8
N2 - The National Registry of Drug-Induced Ocular Side Effects has accumulated 30 cases of suspected allopurinol-induced lens changes. The cataracts associated with this antihyperuricemic agent are initially anterior and posterior lens capsule changes with anterior subcapsular vacuoles. With time, wedge-shaped anterior and posterior cortical haze occurs, along with dense posterior subcapsular cataracts. Histologic studies of these cataracts showed no unique or identifying features. These cases do not prove a cause-and-effect relationship, but raise the suspicion that allopurinol may be cataractogenic in some patients. Additional case reports and lens material should be sent to the National Registry of Drug-Induced Ocular Side Effects, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201.
AB - The National Registry of Drug-Induced Ocular Side Effects has accumulated 30 cases of suspected allopurinol-induced lens changes. The cataracts associated with this antihyperuricemic agent are initially anterior and posterior lens capsule changes with anterior subcapsular vacuoles. With time, wedge-shaped anterior and posterior cortical haze occurs, along with dense posterior subcapsular cataracts. Histologic studies of these cataracts showed no unique or identifying features. These cases do not prove a cause-and-effect relationship, but raise the suspicion that allopurinol may be cataractogenic in some patients. Additional case reports and lens material should be sent to the National Registry of Drug-Induced Ocular Side Effects, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201.
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U2 - 10.1016/0002-9394(82)90067-8
DO - 10.1016/0002-9394(82)90067-8
M3 - Article
C2 - 7114136
AN - SCOPUS:0019968088
SN - 0002-9394
VL - 94
SP - 137
EP - 140
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -