TY - JOUR
T1 - CD7+, CD4-, CD8- acute leukemia
T2 - A syndrome of malignant pluripotent lymphohematopoietic cells
AU - Kurtzberg, J.
AU - Waldmann, T. A.
AU - Davey, M. P.
AU - Bigner, S. H.
AU - Moore, J. O.
AU - Hershfield, M. S.
AU - Haynes, B. F.
PY - 1989
Y1 - 1989
N2 - Following our initial observation of in vivo conversion of CD7+, CD4-, CD8- acute lymphoblastic leukemia (ALL) cells from lymphoid to myeloid lineages (Proc Natl Acad Sci (USA) 81:253, 1984) we have studied eight additional cases of ALL with this leukemic cell phenotype. The CD7+, CD4-, CD8- phenotype was associated with a distinct clinical entity with those affected predominately male (either <35 years or >65 years of age), with frequent mediastinal and/or thymic masses, skin and CNS disease, high peripheral WBC counts, and bone marrow blasts that were morphologically L1 or not ascribable to a specific lineage. These patients did not respond to conventional chemotherapeutic regimens for either acute lymphoid or myeloid leukemias. No common karyotype or T-cell gene rearrangement pattern could be defined. Importantly, seven of eight patients' leukemic cells studied were capable of multilineage (myeloid, erythroid, monocytoid, megakaryocytoid, and lymphoid) differentiation in vitro. Data is presented suggesting that CD7+, CD4-, CD8- leukemias, in many instances, are leukemias of immature hematopoietic cells. The development of novel therapeutic approaches to this form of leukemia will be necessary to alter its poor prognosis.
AB - Following our initial observation of in vivo conversion of CD7+, CD4-, CD8- acute lymphoblastic leukemia (ALL) cells from lymphoid to myeloid lineages (Proc Natl Acad Sci (USA) 81:253, 1984) we have studied eight additional cases of ALL with this leukemic cell phenotype. The CD7+, CD4-, CD8- phenotype was associated with a distinct clinical entity with those affected predominately male (either <35 years or >65 years of age), with frequent mediastinal and/or thymic masses, skin and CNS disease, high peripheral WBC counts, and bone marrow blasts that were morphologically L1 or not ascribable to a specific lineage. These patients did not respond to conventional chemotherapeutic regimens for either acute lymphoid or myeloid leukemias. No common karyotype or T-cell gene rearrangement pattern could be defined. Importantly, seven of eight patients' leukemic cells studied were capable of multilineage (myeloid, erythroid, monocytoid, megakaryocytoid, and lymphoid) differentiation in vitro. Data is presented suggesting that CD7+, CD4-, CD8- leukemias, in many instances, are leukemias of immature hematopoietic cells. The development of novel therapeutic approaches to this form of leukemia will be necessary to alter its poor prognosis.
UR - http://www.scopus.com/inward/record.url?scp=0024535795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024535795&partnerID=8YFLogxK
U2 - 10.1182/blood.v73.2.381.381
DO - 10.1182/blood.v73.2.381.381
M3 - Article
C2 - 2783859
AN - SCOPUS:0024535795
SN - 0006-4971
VL - 73
SP - 381
EP - 390
JO - Blood
JF - Blood
IS - 2
ER -