TY - JOUR
T1 - CDC1 IL-27p28 production predicts vaccine-elicited CD8+ T cell memory and protective immunity
AU - Kilgore, Augustus M.
AU - Pennock, Nathan D.
AU - Kedl, Ross M.
N1 - Publisher Copyright:
© 2020 by The American Association of Immunologists, Inc.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Although adjuvants and formulations are often either empirically derived, or at best judged by their ability to elicit broad inflammation, it would be ideal if specific innate correlates of adaptive immunity could be identified to set a universally applicable benchmark for adjuvant evaluation. Using an IL-27 reporter transgenic mouse model, we show in this study that conventional type 1 dendritic cell IL-27 production in the draining lymph node 12 h after s.c. vaccination directly correlates with downstream CD8+ T cell memory and protective immunity against infectious challenge. This correlation is robust, reproducible, predictive, entirely unique to vaccine biology, and is the only innate correlate of CD8+ T cell immune memory yet to be identified. Our results provide new insights into the basic biology of adjuvant-elicited cellular immunity and have clear implications for the screening and evaluation of novel adjuvants.
AB - Although adjuvants and formulations are often either empirically derived, or at best judged by their ability to elicit broad inflammation, it would be ideal if specific innate correlates of adaptive immunity could be identified to set a universally applicable benchmark for adjuvant evaluation. Using an IL-27 reporter transgenic mouse model, we show in this study that conventional type 1 dendritic cell IL-27 production in the draining lymph node 12 h after s.c. vaccination directly correlates with downstream CD8+ T cell memory and protective immunity against infectious challenge. This correlation is robust, reproducible, predictive, entirely unique to vaccine biology, and is the only innate correlate of CD8+ T cell immune memory yet to be identified. Our results provide new insights into the basic biology of adjuvant-elicited cellular immunity and have clear implications for the screening and evaluation of novel adjuvants.
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U2 - 10.4049/jimmunol.1901357
DO - 10.4049/jimmunol.1901357
M3 - Article
C2 - 31871021
AN - SCOPUS:85078554357
SN - 0022-1767
VL - 204
SP - 510
EP - 517
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -