TY - JOUR
T1 - Cell migration
T2 - Regulation of force on extracellular-matrix-integrin complexes
AU - Sheetz, Michael P.
AU - Felsenfeld, Dan P.
AU - Galbraith, Catherine G.
N1 - Funding Information:
We thank past and present members of the Sheetz lab for helpful comments and many members of the scientific community for discussions, which were essential in forming ideas presented here. D. P. F. was supported by the Cancer Research Fund of the Damon Runyon- Walter Winchell Foundation Fellowship. Work in this lab was supported by the NIH. Additional funding was provided by M.C.N.C. (Research Triangle Park).
PY - 1998/2
Y1 - 1998/2
N2 - Cell migration relies upon forces generated by the cell. Recent studies have provided new insights into the processes by which cells generate and regulate the forces applied to extracellular matrix (ECM)-bound integrins and have led us to the working model described here. In this model, ECM binding to integrins in the front of lamellipodia causes those integrins to attach to the rearward-moving cytoskeleton. Integrin-cytoskeleton attatchments in the front are strengthened as a result of ECM rigidity, enabling the cell to pull itself forward. The reduction in contact area at the rear compared with that at the lamellipodium concentrates the traction forces in the rear on fewer integrin-ECM bonds, facilitating release. In such a model, cell pathfinding and motility can be influenced by ECM rigidity.
AB - Cell migration relies upon forces generated by the cell. Recent studies have provided new insights into the processes by which cells generate and regulate the forces applied to extracellular matrix (ECM)-bound integrins and have led us to the working model described here. In this model, ECM binding to integrins in the front of lamellipodia causes those integrins to attach to the rearward-moving cytoskeleton. Integrin-cytoskeleton attatchments in the front are strengthened as a result of ECM rigidity, enabling the cell to pull itself forward. The reduction in contact area at the rear compared with that at the lamellipodium concentrates the traction forces in the rear on fewer integrin-ECM bonds, facilitating release. In such a model, cell pathfinding and motility can be influenced by ECM rigidity.
UR - http://www.scopus.com/inward/record.url?scp=0031964022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031964022&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(98)80005-6
DO - 10.1016/S0962-8924(98)80005-6
M3 - Comment/debate
C2 - 9695809
AN - SCOPUS:0031964022
SN - 0962-8924
VL - 8
SP - 51
EP - 54
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -