TY - JOUR
T1 - Cellular reprogramming to model and study epigenetic alterations in cancer
AU - Kim, Jungsun
N1 - Funding Information:
This research is supported by the Knight CEDAR ( 68182-906 , 6611019 ), CRUK-OHSU Project Award ( 2018-CRUK-OHSU-001 ), and MRF New Investigator Grant ( GCNCR1042A ) to JK.
Publisher Copyright:
© 2020
PY - 2020/12
Y1 - 2020/12
N2 - Although genetic mutations are required for cancer development, reversible non-genetic alterations also play a pivotal role in cancer progression. Failure of well-orchestrated gene regulation by chromatin states and master transcription factors can be one such non-genetic etiology for cancer development. Master transcription factor-mediated cellular reprogramming of human cancer cells allows us to model cancer progression. Here I cover the history and recent advances in reprogramming cancer cells, followed by lessons from cellular reprogramming of normal cells that may apply to cancer. Lastly, I share my perspective on cellular reprogramming for studying epigenetic alterations that have occurred in tumorigenesis, discuss the current limitations, and propose ways to overcome the obstacles in the reprogramming of cancer.
AB - Although genetic mutations are required for cancer development, reversible non-genetic alterations also play a pivotal role in cancer progression. Failure of well-orchestrated gene regulation by chromatin states and master transcription factors can be one such non-genetic etiology for cancer development. Master transcription factor-mediated cellular reprogramming of human cancer cells allows us to model cancer progression. Here I cover the history and recent advances in reprogramming cancer cells, followed by lessons from cellular reprogramming of normal cells that may apply to cancer. Lastly, I share my perspective on cellular reprogramming for studying epigenetic alterations that have occurred in tumorigenesis, discuss the current limitations, and propose ways to overcome the obstacles in the reprogramming of cancer.
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U2 - 10.1016/j.scr.2020.102062
DO - 10.1016/j.scr.2020.102062
M3 - Review article
C2 - 33202305
AN - SCOPUS:85096091723
SN - 1873-5061
VL - 49
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 102062
ER -