Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation

S. D. Munger, A. P. Lane, H. Zhong, T. Leinders-Zufall, K. W. Yau, F. Zufall, R. R. Reed

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Heteromultimeric cyclic nucleotide-gated (CNG) channels play a central role in the transduction of odorant signals and subsequent adaptation. The contributions of individual subunits to native channel function in olfactory receptor neurons remain unclear. Here, we show that the targeted deletion of the mouse CNGA4 gene, which encodes a modulatory CNG subunit, results in a defect in odorant-dependent adaptation. Channels in excised membrane patches from the CNGA4 null mouse exhibited slower Ca2+-calmodulin-mediated channel desensitization. Thus, the CNGA4 subunit accelerates the Ca2+-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system.

Original languageEnglish (US)
Pages (from-to)2172-2175
Number of pages4
Issue number5549
StatePublished - Dec 7 2001
Externally publishedYes

ASJC Scopus subject areas

  • General


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