Cerebral White Matter Injury: Pathogenesis

Stephen A. Back; Joseph J. Volpe

doi:10.1016/B978-0-323-42876-7.00015-6

Cerebral White Matter Injury: Pathogenesis

Stephen A. Back, Joseph J. Volpe

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

The neuropathology of the encephalopathy of prematurity (see Chapter 14) includes injury to cerebral white matter and, in a major proportion of infants, a variety of neuronal-axonal disturbances. The encephalopathy includes a broad spectrum of initiating destructive events or disturbances in cellular maturation that are followed by widespread disruptions in cerebral white and gray matter growth and neuronal connectivity. This chapter emphasizes the pathophysiology of the most consistent and well-defined feature of the encephalopathy, injury to the cerebral white matter.

Original language	English (US)
Title of host publication	Volpe's Neurology of the Newborn
Publisher	Elsevier
Pages	405-424.e8
ISBN (Electronic)	9780323428767
ISBN (Print)	9780323508650
DOIs	https://doi.org/10.1016/B978-0-323-42876-7.00015-6
State	Published - Jan 1 2018

Keywords

cerebral blood flow
inflammation
maternal-fetal infection
microglia
oligodendrocyte

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-323-42876-7.00015-6

Cite this

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AB - The neuropathology of the encephalopathy of prematurity (see Chapter 14) includes injury to cerebral white matter and, in a major proportion of infants, a variety of neuronal-axonal disturbances. The encephalopathy includes a broad spectrum of initiating destructive events or disturbances in cellular maturation that are followed by widespread disruptions in cerebral white and gray matter growth and neuronal connectivity. This chapter emphasizes the pathophysiology of the most consistent and well-defined feature of the encephalopathy, injury to the cerebral white matter.

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KW - inflammation

KW - maternal-fetal infection

KW - microglia

KW - oligodendrocyte

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SN - 9780323508650

SP - 405-424.e8

BT - Volpe's Neurology of the Newborn

PB - Elsevier

ER -

Cerebral White Matter Injury: Pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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