Cerebral White Matter Injury: Pathogenesis

Stephen A. Back, Joseph J. Volpe

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


The neuropathology of the encephalopathy of prematurity (see Chapter 14) includes injury to cerebral white matter and, in a major proportion of infants, a variety of neuronal-axonal disturbances. The encephalopathy includes a broad spectrum of initiating destructive events or disturbances in cellular maturation that are followed by widespread disruptions in cerebral white and gray matter growth and neuronal connectivity. This chapter emphasizes the pathophysiology of the most consistent and well-defined feature of the encephalopathy, injury to the cerebral white matter.

Original languageEnglish (US)
Title of host publicationVolpe's Neurology of the Newborn
ISBN (Electronic)9780323428767
ISBN (Print)9780323508650
StatePublished - Jan 1 2018


  • cerebral blood flow
  • inflammation
  • maternal-fetal infection
  • microglia
  • oligodendrocyte

ASJC Scopus subject areas

  • Medicine(all)


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