TY - JOUR
T1 - Change in Cognitive Capabilities in the Oldest Old
T2 - The Effects of Proximity to Death in Genetically Related Individuals over A 6-Year Period
AU - Johansson, Boo
AU - Hofer, Scott M.
AU - Allaire, Jason C.
AU - Maldonado-Molina, Mildred M.
AU - Piccinin, Andrea M.
AU - Berg, Stig
AU - Pedersen, Nancy L.
AU - McClearn, Gerald E.
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2004/3
Y1 - 2004/3
N2 - Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1), who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.
AB - Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1), who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.
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U2 - 10.1037/0882-7974.19.1.145
DO - 10.1037/0882-7974.19.1.145
M3 - Article
C2 - 15065938
AN - SCOPUS:1542723365
SN - 0882-7974
VL - 19
SP - 145
EP - 156
JO - Psychology and Aging
JF - Psychology and Aging
IS - 1
ER -