TY - JOUR
T1 - Characterization of basic protein-specific T cell lines selected from Lewis rats with relapsing experimental autoimmune encephalomyelitis
AU - Bourdette, Dennis N.
AU - Turner, M. Joseph
AU - Vandenbark, Arthur A.
AU - Offner, Halina
N1 - Funding Information:
search Foundation of Oregon and NIH grants NS 23444 and NS 23221. We thank Dr. George Hashim and Dr. C.-J. Chou for generously providing some of the materials used in this study. We thank Bozena Celnik for her excellent technical support and Lynn Riley and Karin Coffee for their secretarial assistance.
PY - 1990/1
Y1 - 1990/1
N2 - Relapsing experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by intraperitoneal immunization with guinea pig whole central nervous system tissue. Basic protein (BP)-specific T cell lines selected from rats with relapsing EAE proliferated in response to BP, the 44-89 peptidase fragment of BP and the synthetic peptide, S72-89, as did lines selected from rats with non-relapsing EAE induced by immunization with guinea pig BP. BP-specific T cell lines selected from rats with relapsing EAE transferred acute but not relapsing EAE. BP-specific T cell lines selected from Lewis rats with relapsing EAE appear not to differ from those selected from rats with non-relapsing EAE.
AB - Relapsing experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by intraperitoneal immunization with guinea pig whole central nervous system tissue. Basic protein (BP)-specific T cell lines selected from rats with relapsing EAE proliferated in response to BP, the 44-89 peptidase fragment of BP and the synthetic peptide, S72-89, as did lines selected from rats with non-relapsing EAE induced by immunization with guinea pig BP. BP-specific T cell lines selected from rats with relapsing EAE transferred acute but not relapsing EAE. BP-specific T cell lines selected from Lewis rats with relapsing EAE appear not to differ from those selected from rats with non-relapsing EAE.
KW - Myelin basic protein-specific T cell line
KW - Relapsing experimental autoimmune encephalomyelitis
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U2 - 10.1016/0165-5728(90)90123-5
DO - 10.1016/0165-5728(90)90123-5
M3 - Article
C2 - 1688445
AN - SCOPUS:0025120159
SN - 0165-5728
VL - 26
SP - 81
EP - 85
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1
ER -