Characterization of individual ultrasound microbubble dynamics with a light-scattering system

Mark J. Hsu, Mohammad Eghtedari, Andrew P. Goodwin, David J. Hall, Robert F. Mattrey, Sadik C. Esener

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.

Original languageEnglish (US)
Article number067002
JournalJournal of biomedical optics
Issue number6
StatePublished - Jun 2011
Externally publishedYes


  • acousto-optics
  • medical imaging
  • ultrasonics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering


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