TY - JOUR
T1 - Cholesterol metabolism and suicidality in smith-lemli-opitz syndrome carriers
AU - Lalovic, Aleksandra
AU - Merkens, Louise
AU - Russell, Laura
AU - Arsenault-Lapierre, Geneviève
AU - Nowaczyk, Malgorzata J.M.
AU - Porter, Forbes D.
AU - Steiner, Robert D.
AU - Turecki, Gustavo
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/11
Y1 - 2004/11
N2 - Objective: The authors examined the relationship between cholesterol metabolism and suicidality in carriers of Smith-Lemli-Opitz syndrome and their families. This population has a partial deficiency in 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the last step in cholesterol biosynthesis. Method: Suicidal behavior, depression, misuse of alcohol and drugs, and family history of psychopathology, including attempted or completed suicide, were assessed by structured interview in 51 carriers of Smith-Lemli-Opitz syndrome and 54 matched comparison subjects. Results: There were significantly more suicide attempters and completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects, but family history of psychopathology did not significantly differ between the groups. More suicide attempts were reported among Smith-Lemli-Opitz syndrome carriers than among the comparison subjects. Conclusions: These results, based on a unique study design, provide additional evidence supporting the relationship between cholesterol metabolism and suicidal behavior.
AB - Objective: The authors examined the relationship between cholesterol metabolism and suicidality in carriers of Smith-Lemli-Opitz syndrome and their families. This population has a partial deficiency in 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the last step in cholesterol biosynthesis. Method: Suicidal behavior, depression, misuse of alcohol and drugs, and family history of psychopathology, including attempted or completed suicide, were assessed by structured interview in 51 carriers of Smith-Lemli-Opitz syndrome and 54 matched comparison subjects. Results: There were significantly more suicide attempters and completers among the biological relatives of Smith-Lemli-Opitz syndrome carriers than comparison subjects, but family history of psychopathology did not significantly differ between the groups. More suicide attempts were reported among Smith-Lemli-Opitz syndrome carriers than among the comparison subjects. Conclusions: These results, based on a unique study design, provide additional evidence supporting the relationship between cholesterol metabolism and suicidal behavior.
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U2 - 10.1176/appi.ajp.161.11.2123
DO - 10.1176/appi.ajp.161.11.2123
M3 - Article
C2 - 15514417
AN - SCOPUS:7444235795
SN - 0002-953X
VL - 161
SP - 2123
EP - 2125
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 11
ER -