Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Mark A. Malesker; Priscilla Callahan-Lyon; J. Mark Madison; Belinda Ireland; Richard S. Irwin; Todd M. Adams; Kenneth W. Altman; Elie Azoulay; Alan F. Barker; Surinder S. Birring; Fiona Blackhall; Donald C. Bolser; Louis Philippe Boulet; Sidney S. Braman; Christopher Brightling; Anne B. Chang; Paul Davenport; Ali A. El Solh; Patricio Escalante; Stephen K. Field; Dina Fisher; Cynthia T. French; Peter Gibson; Cameron Grant; Susan M. Harding; Anthony Harnden; Adam T. Hill; Peter J. Kahrilas; Joanne Kavanagh; Karina A. Keogh; Kefang Lai; Andrew P. Lane; Craig Lilly; Kaiser Lim; Mark Lown; Stuart Mazzone; Lorcan McGarvey; Alex Molassoitis; M. Hassan Murad; Mangala Narasimhan; John Oppenheimer; Mark Rosen; Bruce Rubin; Richard J. Russell; Jay H. Ryu; Sonal Singh; Maeve P. Smith; Susan M. Tarlo; Anne E. Vertigan

doi:10.1016/j.chest.2020.02.015

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Mark A. Malesker, Priscilla Callahan-Lyon, J. Mark Madison, Belinda Ireland, Richard S. Irwin, Todd M. Adams, Kenneth W. Altman, Elie Azoulay, Alan F. Barker, Surinder S. Birring, Fiona Blackhall, Donald C. Bolser, Louis Philippe Boulet, Sidney S. Braman, Christopher Brightling, Anne B. Chang, Paul Davenport, Ali A. El Solh, Patricio Escalante, Stephen K. FieldDina Fisher, Cynthia T. French, Peter Gibson, Cameron Grant, Susan M. Harding, Anthony Harnden, Adam T. Hill, Peter J. Kahrilas, Joanne Kavanagh, Karina A. Keogh, Kefang Lai, Andrew P. Lane, Craig Lilly, Kaiser Lim, Mark Lown, Stuart Mazzone, Lorcan McGarvey, Alex Molassoitis, M. Hassan Murad, Mangala Narasimhan, John Oppenheimer, Mark Rosen, Bruce Rubin, Richard J. Russell, Jay H. Ryu, Sonal Singh, Maeve P. Smith, Susan M. Tarlo, Anne E. Vertigan

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient's cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB prevent or reduce the occurrence of acute CB exacerbations? Studies of adult patients with CB were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the CHEST organization methodology. Results: The search strategy used an assortment of descriptors and assessments to identify studies of chronic cough due to CB. Conclusions: The evidence supporting the management of chronic cough due to CB is limited overall and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identifies gaps in our knowledge and areas for future research.

Original language	English (US)
Pages (from-to)	705-718
Number of pages	14
Journal	CHEST
Volume	158
Issue number	2
DOIs	https://doi.org/10.1016/j.chest.2020.02.015
State	Published - Aug 2020

Keywords

chronic bronchitis
chronic cough
nonpharmacological treatment
pharmacological treatment

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.chest.2020.02.015

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Malesker, M. A., Callahan-Lyon, P., Madison, J. M., Ireland, B., Irwin, R. S., Adams, T. M., Altman, K. W., Azoulay, E., Barker, A. F., Birring, S. S., Blackhall, F., Bolser, D. C., Boulet, L. P., Braman, S. S., Brightling, C., Chang, A. B., Davenport, P., El Solh, A. A., Escalante, P., ... Vertigan, A. E. (2020). Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report. CHEST, 158(2), 705-718. https://doi.org/10.1016/j.chest.2020.02.015

Malesker, MA, Callahan-Lyon, P, Madison, JM, Ireland, B, Irwin, RS, Adams, TM, Altman, KW, Azoulay, E, Barker, AF, Birring, SS, Blackhall, F, Bolser, DC, Boulet, LP, Braman, SS, Brightling, C, Chang, AB, Davenport, P, El Solh, AA, Escalante, P, Field, SK, Fisher, D, French, CT, Gibson, P, Grant, C, Harding, SM, Harnden, A, Hill, AT, Kahrilas, PJ, Kavanagh, J, Keogh, KA, Lai, K, Lane, AP, Lilly, C, Lim, K, Lown, M, Mazzone, S, McGarvey, L, Molassoitis, A, Murad, MH, Narasimhan, M, Oppenheimer, J, Rosen, M, Rubin, B, Russell, RJ, Ryu, JH, Singh, S, Smith, MP, Tarlo, SM & Vertigan, AE 2020, 'Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report', CHEST, vol. 158, no. 2, pp. 705-718. https://doi.org/10.1016/j.chest.2020.02.015

@article{8db686208bc54f788c37677c3c97b7e3,

title = "Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report",

abstract = "Background: Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient's cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB prevent or reduce the occurrence of acute CB exacerbations? Studies of adult patients with CB were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the CHEST organization methodology. Results: The search strategy used an assortment of descriptors and assessments to identify studies of chronic cough due to CB. Conclusions: The evidence supporting the management of chronic cough due to CB is limited overall and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identifies gaps in our knowledge and areas for future research.",

keywords = "chronic bronchitis, chronic cough, nonpharmacological treatment, pharmacological treatment",

author = "Malesker, {Mark A.} and Priscilla Callahan-Lyon and Madison, {J. Mark} and Belinda Ireland and Irwin, {Richard S.} and Adams, {Todd M.} and Altman, {Kenneth W.} and Elie Azoulay and Barker, {Alan F.} and Birring, {Surinder S.} and Fiona Blackhall and Bolser, {Donald C.} and Boulet, {Louis Philippe} and Braman, {Sidney S.} and Christopher Brightling and Chang, {Anne B.} and Paul Davenport and {El Solh}, {Ali A.} and Patricio Escalante and Field, {Stephen K.} and Dina Fisher and French, {Cynthia T.} and Peter Gibson and Cameron Grant and Harding, {Susan M.} and Anthony Harnden and Hill, {Adam T.} and Kahrilas, {Peter J.} and Joanne Kavanagh and Keogh, {Karina A.} and Kefang Lai and Lane, {Andrew P.} and Craig Lilly and Kaiser Lim and Mark Lown and Stuart Mazzone and Lorcan McGarvey and Alex Molassoitis and Murad, {M. Hassan} and Mangala Narasimhan and John Oppenheimer and Mark Rosen and Bruce Rubin and Russell, {Richard J.} and Ryu, {Jay H.} and Sonal Singh and Smith, {Maeve P.} and Tarlo, {Susan M.} and Vertigan, {Anne E.}",

note = "Funding Information: Author contributions: M. A. M. P. C.-L. and J. M. M were the topic editors for this article and developed the key question using the Population, Intervention, Comparator, Outcome (PICO) format in collaboration with R. S. I. B. I. was the appointed methodologist and was among the investigators who conducted the systematic review that formed the basis for the suggestions. M. A. M. wrote the first draft; P. C.-L. B. I. J. M. M. and R. S. I. reviewed and contributed to subsequent versions. Financial/nonfinancial disclosures: The authors have reported to CHEST the following: J. M. M. received monetary support for consultancy at a 1-day, US Chronic Cough Expert Input Forum sponsored by Merck & Co. Inc. None declared (M. A. M. P. C. L. B. I. R. S. I.). ∗Expert Cough Panel Collaborators: Todd M. Adams, MD (Webhannet Internal Medicine Associates of York Hospital, Wells, ME), Kenneth W. Altman, MD, PhD (Geisinger Commonwealth School of Medicine, Danville, PA), Elie Azoulay, MD, PhD (University of Paris, Paris, France), Alan F. Barker, MD (Oregon Health & Science University, Portland, OR), Surinder S. Birring, MB ChB, MD (Division of Asthma, Allergy and Lung Biology, King's College London, London, England), Fiona Blackhall, MD, PhD (Department of Medical Oncology, University of Manchester, Manchester, England), Donald C. Bolser, PhD (College of Veterinary Medicine, University of Florida, Gainesville, FL), Louis-Philippe Boulet, MD, FCCP (Institut universitaire de cardiologie et de pneumologie de Qu{\'e}bec, Quebec, QC, Canada), Sidney S. Braman, MD, FCCP (Mount Sinai Hospital, New York, NY), Christopher Brightling, MBBS, PhD, FCCP (University of Leicester, Glenfield Hospital, Leicester, England), Priscilla Callahan-Lyon, MD (Adamstown, MD), Anne B. Chang, MBBS, PhD, MPH (Royal Children's Hospital, Brisbane, QLD, Australia), Paul Davenport, PhD (Department of Physiological Sciences, University of Florida, Gainesville FL), Ali A. El Solh, MD, MPH (University at Buffalo, State University of New York, Buffalo, NY), Patricio Escalante, MD, MSc, FCCP (Mayo Clinic, Rochester, MN), Stephen K. Field, MD (University of Calgary, Calgary, AB, Canada), Dina Fisher, MD, MSc (Respiratory Medicine, University of Calgary, Calgary, AB, Canada), Cynthia T. French, PhD, FCCP (UMass Memorial Medical Center, Worcester, MA), Peter Gibson, MBBS (Hunter Medical Research Institute, New Lambton Heights, NSW, Australia), Cameron Grant, MBChB, PhD (University of Auckland, Auckland, New Zealand), Susan M. Harding, MD, FCCP (Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL), Anthony Harnden, MB ChB, MSc (University of Oxford, Oxford, England), Adam T. Hill, MBChB, MD (Royal Infirmary and University of Edinburgh, Edinburgh, Scotland), Richard S. Irwin, MD, Master FCCP (UMass Memorial Medical Center, Worcester, MA), Peter J. Kahrilas, MD (Feinberg School of Medicine, Northwestern University, Chicago, IL), Joanne Kavanagh, MBChB (Division of Asthma, Allergy and Lung Biology, King's College London, London, England), Karina A. Keogh, MD (Mayo Clinic, Rochester, MN), Kefang Lai, MD, PhD (First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China), Andrew P. Lane, MD (Johns Hopkins University School of Medicine, Baltimore, MD), Craig Lilly, MD, FCCP (UMass Memorial Medical Center, Worcester, MA), Kaiser Lim, MD (Mayo Clinic, Rochester, MN), Mark Lown, MBBS, PhD (University of Southampton, Aldermoor Health Centre, Aldermoor Close, Southampton, England), J. Mark Madison, MD, FCCP (UMass Memorial Medical Center, Worcester, MA), Mark A. Malesker, PharmD, FCCP (Creighton University School of Pharmacy and Health Professions, Omaha, NE), Stuart Mazzone, PhD, FCCP (University of Queensland, Brisbane, QLD, Australia), Lorcan McGarvey, MD (Queen's University Belfast, Belfast, Northern Ireland), Alex Molassoitis, PhD, MSc, RN (Hong Kong Polytechnic University, Hong Kong, China), M. Hassan Murad, MD, MPH (Mayo Clinic, Rochester, MN), Mangala Narasimhan, DO, FCCP (Hofstra-Northwell Health, Manhasset, NY), John Oppenheimer, MD (University of Medicine and Dentistry of New Jersey-Rutgers University, Newark, NJ), Mark Rosen, MD, Master FCCP (Icahn School of Medicine at Mount Sinai, New York, NY), Bruce Rubin, MEngr, MD, MBA (Virginia Commonwealth University, Richmond, VA), Richard J. Russell, MBBS (University of Leicester, Glenfield Hospital, Leicester, England), Jay H. Ryu, MD, FCCP (Mayo Clinic, Rochester, MN), Sonal Singh, MD, MPH (UMass Memorial Medical Center, Worcester, MA), Maeve P. Smith, MB ChB, MD (University of Alberta, Edmonton, AB, Canada), Susan M. Tarlo, MBBS, FCCP (Toronto Western Hospital, Toronto, ON, Canada), Anne E. Vertigan, PhD, MBA, BAppSc (SpPath) (John Hunter Hospital, New Lambton Heights, NSW, Australia), Other contributions: We thank Nancy Harger, MLS, clinical service librarians working in the University of Massachusetts Medical School Library, Worcester, MA, who undertook all the searches for this systematic review. Role of sponsors: The American College of Chest Physicians was the sole supporter of these guidelines, this article, and the innovations addressed within. Additional information: The e-Appendix can be found in the Supplemental Materials section of the online article. CHEST Expert Panel Collaborator, Mark Rosen, MD, FCCP, died July 2, 2019. FUNDING/SUPPORT: CHEST was the sole supporter of these guidelines, this article, and the innovation addressed within. Publisher Copyright: {\textcopyright} 2020 American College of Chest Physicians",

year = "2020",

month = aug,

doi = "10.1016/j.chest.2020.02.015",

language = "English (US)",

volume = "158",

pages = "705--718",

journal = "Diseases of the chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

number = "2",

}

TY - JOUR

T1 - Chronic Cough Due to Stable Chronic Bronchitis

T2 - CHEST Expert Panel Report

AU - Malesker, Mark A.

AU - Callahan-Lyon, Priscilla

AU - Madison, J. Mark

AU - Ireland, Belinda

AU - Irwin, Richard S.

AU - Adams, Todd M.

AU - Altman, Kenneth W.

AU - Azoulay, Elie

AU - Barker, Alan F.

AU - Birring, Surinder S.

AU - Blackhall, Fiona

AU - Bolser, Donald C.

AU - Boulet, Louis Philippe

AU - Braman, Sidney S.

AU - Brightling, Christopher

AU - Chang, Anne B.

AU - Davenport, Paul

AU - El Solh, Ali A.

AU - Escalante, Patricio

AU - Field, Stephen K.

AU - Fisher, Dina

AU - French, Cynthia T.

AU - Gibson, Peter

AU - Grant, Cameron

AU - Harding, Susan M.

AU - Harnden, Anthony

AU - Hill, Adam T.

AU - Kahrilas, Peter J.

AU - Kavanagh, Joanne

AU - Keogh, Karina A.

AU - Lai, Kefang

AU - Lane, Andrew P.

AU - Lilly, Craig

AU - Lim, Kaiser

AU - Lown, Mark

AU - Mazzone, Stuart

AU - McGarvey, Lorcan

AU - Molassoitis, Alex

AU - Murad, M. Hassan

AU - Narasimhan, Mangala

AU - Oppenheimer, John

AU - Rosen, Mark

AU - Rubin, Bruce

AU - Russell, Richard J.

AU - Ryu, Jay H.

AU - Singh, Sonal

AU - Smith, Maeve P.

AU - Tarlo, Susan M.

AU - Vertigan, Anne E.

N1 - Funding Information: Author contributions: M. A. M. P. C.-L. and J. M. M were the topic editors for this article and developed the key question using the Population, Intervention, Comparator, Outcome (PICO) format in collaboration with R. S. I. B. I. was the appointed methodologist and was among the investigators who conducted the systematic review that formed the basis for the suggestions. M. A. M. wrote the first draft; P. C.-L. B. I. J. M. M. and R. S. I. reviewed and contributed to subsequent versions. Financial/nonfinancial disclosures: The authors have reported to CHEST the following: J. M. M. received monetary support for consultancy at a 1-day, US Chronic Cough Expert Input Forum sponsored by Merck & Co. Inc. None declared (M. A. M. P. C. L. B. I. R. S. I.). ∗Expert Cough Panel Collaborators: Todd M. Adams, MD (Webhannet Internal Medicine Associates of York Hospital, Wells, ME), Kenneth W. Altman, MD, PhD (Geisinger Commonwealth School of Medicine, Danville, PA), Elie Azoulay, MD, PhD (University of Paris, Paris, France), Alan F. Barker, MD (Oregon Health & Science University, Portland, OR), Surinder S. Birring, MB ChB, MD (Division of Asthma, Allergy and Lung Biology, King's College London, London, England), Fiona Blackhall, MD, PhD (Department of Medical Oncology, University of Manchester, Manchester, England), Donald C. Bolser, PhD (College of Veterinary Medicine, University of Florida, Gainesville, FL), Louis-Philippe Boulet, MD, FCCP (Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC, Canada), Sidney S. Braman, MD, FCCP (Mount Sinai Hospital, New York, NY), Christopher Brightling, MBBS, PhD, FCCP (University of Leicester, Glenfield Hospital, Leicester, England), Priscilla Callahan-Lyon, MD (Adamstown, MD), Anne B. Chang, MBBS, PhD, MPH (Royal Children's Hospital, Brisbane, QLD, Australia), Paul Davenport, PhD (Department of Physiological Sciences, University of Florida, Gainesville FL), Ali A. El Solh, MD, MPH (University at Buffalo, State University of New York, Buffalo, NY), Patricio Escalante, MD, MSc, FCCP (Mayo Clinic, Rochester, MN), Stephen K. Field, MD (University of Calgary, Calgary, AB, Canada), Dina Fisher, MD, MSc (Respiratory Medicine, University of Calgary, Calgary, AB, Canada), Cynthia T. French, PhD, FCCP (UMass Memorial Medical Center, Worcester, MA), Peter Gibson, MBBS (Hunter Medical Research Institute, New Lambton Heights, NSW, Australia), Cameron Grant, MBChB, PhD (University of Auckland, Auckland, New Zealand), Susan M. Harding, MD, FCCP (Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL), Anthony Harnden, MB ChB, MSc (University of Oxford, Oxford, England), Adam T. Hill, MBChB, MD (Royal Infirmary and University of Edinburgh, Edinburgh, Scotland), Richard S. Irwin, MD, Master FCCP (UMass Memorial Medical Center, Worcester, MA), Peter J. Kahrilas, MD (Feinberg School of Medicine, Northwestern University, Chicago, IL), Joanne Kavanagh, MBChB (Division of Asthma, Allergy and Lung Biology, King's College London, London, England), Karina A. Keogh, MD (Mayo Clinic, Rochester, MN), Kefang Lai, MD, PhD (First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China), Andrew P. Lane, MD (Johns Hopkins University School of Medicine, Baltimore, MD), Craig Lilly, MD, FCCP (UMass Memorial Medical Center, Worcester, MA), Kaiser Lim, MD (Mayo Clinic, Rochester, MN), Mark Lown, MBBS, PhD (University of Southampton, Aldermoor Health Centre, Aldermoor Close, Southampton, England), J. Mark Madison, MD, FCCP (UMass Memorial Medical Center, Worcester, MA), Mark A. Malesker, PharmD, FCCP (Creighton University School of Pharmacy and Health Professions, Omaha, NE), Stuart Mazzone, PhD, FCCP (University of Queensland, Brisbane, QLD, Australia), Lorcan McGarvey, MD (Queen's University Belfast, Belfast, Northern Ireland), Alex Molassoitis, PhD, MSc, RN (Hong Kong Polytechnic University, Hong Kong, China), M. Hassan Murad, MD, MPH (Mayo Clinic, Rochester, MN), Mangala Narasimhan, DO, FCCP (Hofstra-Northwell Health, Manhasset, NY), John Oppenheimer, MD (University of Medicine and Dentistry of New Jersey-Rutgers University, Newark, NJ), Mark Rosen, MD, Master FCCP (Icahn School of Medicine at Mount Sinai, New York, NY), Bruce Rubin, MEngr, MD, MBA (Virginia Commonwealth University, Richmond, VA), Richard J. Russell, MBBS (University of Leicester, Glenfield Hospital, Leicester, England), Jay H. Ryu, MD, FCCP (Mayo Clinic, Rochester, MN), Sonal Singh, MD, MPH (UMass Memorial Medical Center, Worcester, MA), Maeve P. Smith, MB ChB, MD (University of Alberta, Edmonton, AB, Canada), Susan M. Tarlo, MBBS, FCCP (Toronto Western Hospital, Toronto, ON, Canada), Anne E. Vertigan, PhD, MBA, BAppSc (SpPath) (John Hunter Hospital, New Lambton Heights, NSW, Australia), Other contributions: We thank Nancy Harger, MLS, clinical service librarians working in the University of Massachusetts Medical School Library, Worcester, MA, who undertook all the searches for this systematic review. Role of sponsors: The American College of Chest Physicians was the sole supporter of these guidelines, this article, and the innovations addressed within. Additional information: The e-Appendix can be found in the Supplemental Materials section of the online article. CHEST Expert Panel Collaborator, Mark Rosen, MD, FCCP, died July 2, 2019. FUNDING/SUPPORT: CHEST was the sole supporter of these guidelines, this article, and the innovation addressed within. Publisher Copyright: © 2020 American College of Chest Physicians

PY - 2020/8

Y1 - 2020/8

N2 - Background: Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient's cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB prevent or reduce the occurrence of acute CB exacerbations? Studies of adult patients with CB were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the CHEST organization methodology. Results: The search strategy used an assortment of descriptors and assessments to identify studies of chronic cough due to CB. Conclusions: The evidence supporting the management of chronic cough due to CB is limited overall and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identifies gaps in our knowledge and areas for future research.

AB - Background: Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient's cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB prevent or reduce the occurrence of acute CB exacerbations? Studies of adult patients with CB were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the CHEST organization methodology. Results: The search strategy used an assortment of descriptors and assessments to identify studies of chronic cough due to CB. Conclusions: The evidence supporting the management of chronic cough due to CB is limited overall and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identifies gaps in our knowledge and areas for future research.

KW - chronic bronchitis

KW - chronic cough

KW - nonpharmacological treatment

KW - pharmacological treatment

UR - http://www.scopus.com/inward/record.url?scp=85087477599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85087477599&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2020.02.015

DO - 10.1016/j.chest.2020.02.015

M3 - Article

C2 - 32105719

AN - SCOPUS:85087477599

SN - 0012-3692

VL - 158

SP - 705

EP - 718

JO - Diseases of the chest

JF - Diseases of the chest

IS - 2

ER -

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

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