Circadian misalignment in major depressive disorder

Jonathan Emens, Alfred Lewy, John Mark Kinzie, Diana Arntz, Jennifer Rough

Research output: Contribution to journalArticlepeer-review

199 Scopus citations


It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.

Original languageEnglish (US)
Pages (from-to)259-261
Number of pages3
JournalPsychiatry Research
Issue number3
StatePublished - Aug 15 2009


  • Circadian rhythms
  • Depression
  • Dim light melatonin onset (DLMO)
  • Melatonin
  • Phase angle difference (PAD)
  • Sleep

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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