Clearance of glutamate inside the synapse and beyond

Dwight E. Bergles, Jeffrey S. Diamond, Craig E. Jahr

Research output: Contribution to journalArticlepeer-review

289 Scopus citations


The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glutamate in the synaptic cleft does not attain levels previously suggested. In contrast, recordings from glial cells and studies of extrasynaptic receptor activation indicate that significant quantities of glutamate escape from the cleft following exocytosis. Determining the amount of glutamate efflux from the synaptic cleft and the distance it diffuses is critical to issues of synaptic specificity and the induction of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1999

ASJC Scopus subject areas

  • General Neuroscience


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